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De Novo Triacylglycerol Biosynthesis TG(15:0/18:3(9Z,12Z,15Z)/15:0)
smpdb.ca/view/SMP0017458MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
Pirbuterol
go.drugbank.com/drugs/DB01291ApprovedWithdrawnin a concentration between 10-50%. … Pirbuterol is a beta-2 adrenergic bronchodilator.
Categories: Compounds used in a research, industrial, or household settingRolapitant
go.drugbank.com/drugs/DB09291ApprovedInvestigationallate-phase CINV during the first 120 hours post-chemotherapy. … Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme CYP3A4 and has a long elimination half-life, allowing a single dose to prevent both acute and
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsEfanesoctocog alfa
go.drugbank.com/drugs/DB16662ApprovedInvestigationalEndogenous VWF protects FVIII from degradation but also sets a half-life of approximately 15 to 19 h. … episodes in patients with hemophilia A.
Splicing factor 3B subunit 1
go.drugbank.com/bio_entities/BE0009359TargetHumansComponent of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310, PubMed:36104565). The 17S U2...
Synonyms: SAP 155, Spliceosome-associated protein 155Inositol nicotinate
go.drugbank.com/drugs/DB08949ApprovedWithdrawnIt is used in food supplements as a source of niacin (vitamin B3), where hydrolysis of 1 g (1.23 mmol) inositol hexanicotinate yields 0.91 g nicotinic acid and 0.22 g inositol. … Inositol nicotinate, also known as Inositol hexaniacinate/hexanicotinate or "no-flush niacin", is a niacin ester and vasodilator.
Mixtures: Inositol Nicotinate 250 mg, Inositol Nicotinate 250 mgLevacetylmethadol
go.drugbank.com/drugs/DB01227ApprovedWithdrawnLevacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic IndexPhosphatidylethanolamine Biosynthesis PE(15:0/18:3(9Z,12Z,15Z))
smpdb.ca/view/SMP0015124MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
Drugs: Choline · Serine · Phosphatidyl serine · ATP · Cytidine-5'-Triphosphate · Ethanolamine +1 moreFutibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigationalFutibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and … [A253193,A253198] As a novel inhibitor of FGFR, futibatinib was first approved by the FDA in September 2022 to treat different types of intrahepatic cholangiocarcinoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates