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Displaying results 2401 - 2410 of 10000 in total
  1. Pathway

    Alprenolol Action Pathway

    smpdb.ca/view/SMP0000297
    Drug action

    Alprenolol (also known as alfeprol, alpheprol or alprenololum) a beta blocker (non-selective) that block beta-1 adrenergic receptor in heart. … In the juxtaglomerular apparatus, alprenolol can also bind to beta-2 receptors to prevent the production and release of renin (also known as angiotensinogenase).

    Drugs: ATP · Alprenolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  2. Pathway

    Betaxolol Action Pathway

    smpdb.ca/view/SMP0000299
    Drug action

    Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to reduced heart rate, cardiac output, and decreased blood pressure.

    Drugs: ATP · Betaxolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  3. Pathway

    Esmolol Action Pathway

    smpdb.ca/view/SMP0000301
    Drug action

    Esmolol is rapidly metabolized in red blood cells, and once metabolized it is inactivated, giving it a short time of activity within the body. … When esmolol binds, it causes the rate and force of these heart contractions to be decreased, in order to help treat supraventricular tachycardia.

    Drugs: ATP · Esmolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  4. Pathway

    Nadolol Action Pathway

    smpdb.ca/view/SMP0000303
    Drug action

    Nadolol can also bind beta-2 adrenergic receptors in juxtaglomerular apparatus and bronchiole smooth muscle. … In bronchiole smooth muscle, binding of nadolol to beta-2 adrenergic receptors can also prevent vasoconstriction.

    Drugs: ATP · Nadolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  5. Pathway

    Oxprenolol Action Pathway

    smpdb.ca/view/SMP0000304
    Drug action

    Oxprenolol can also bind beta-2 adrenergic receptors in juxtaglomerular apparatus and bronchiole smooth muscle. … In bronchiole smooth muscle, binding of oxprenolol to beta-2 adrenergic receptors can also prevent vasoconstriction.

    Drugs: ATP · Potassium cation · Calcium · Oxprenolol
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  6. Pathway

    Propranolol Action Pathway

    smpdb.ca/view/SMP0000307
    Drug action

    Propranolol, a non-cardioselective beta blocker, inhibits sympathetic stimulation by competing with neurotransmitters like catecholamines to bind beta(1)-adrenergic receptors of the heart and vascular smooth muscle. Propranolol binding r...

    Drugs: ATP · Propranolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  7. Pathway

    Quinidine Action Pathway

    smpdb.ca/view/SMP0000323
    Drug action

    I-Kr block results in action potential prolongation. … This pathway illustrates the quinidine targets involved in antiarrhythmic therapy.

    Drugs: ATP · Quinidine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  8. Pathway

    Disopyramide Action Pathway

    smpdb.ca/view/SMP0000325
    Drug action

    This pathway illustrates the disopyramide targets involved in antiarrhythmic therapy. … The positive outflow of potassium ions aids in maintaining the negative intracellular electric potential.

    Drugs: ATP · Disopyramide · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  9. Pathway

    Nebivolol Action Pathway

    smpdb.ca/view/SMP0000366
    Drug action

    Nebivolol can also prevent release of renin (a hormone from kidneys), which can result in reduced level of constriction of blood vessels. … Nebivolol (also known as Bystolic or Nebivololum) is a β1-receptor blocker (selective β1-receptor antagonist) that can bind and inhibit Beta-1 adrenergic receptor in muscule and heart.

    Drugs: ATP · Potassium cation · Calcium · Nebivolol
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  10. Pathway

    Verapamil Action Pathway

    smpdb.ca/view/SMP0000375
    Drug action

    CCBs target L-type calcium channels, the major channel in muscle cells that mediates contraction. … There are at least five different types of calcium channels in Homo sapiens: L-, N-, P/Q-, R- and T-type.

    Drugs: ATP · Verapamil · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2