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Tumor necrosis factor receptor superfamily member 17
go.drugbank.com/bio_entities/BE0010010TargetHumansReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK
Polypeptides: Tumor necrosis factor receptor superfamily member 17Function: signaling receptor activityC-X-C chemokine receptor type 2
go.drugbank.com/bio_entities/BE0010516TargetHumansReceptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils.
Polypeptides: C-X-C chemokine receptor type 2Synonyms: GRO/MGSA receptor, IL-8 receptor type 2Tumor necrosis factor receptor superfamily member 16
go.drugbank.com/bio_entities/BE0010540TargetHumansLow affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Polypeptides: Tumor necrosis factor receptor superfamily member 16Synonyms: NGF receptor, Low affinity neurotrophin receptor p75NTRAntiviral innate immune response receptor RIG-I
go.drugbank.com/bio_entities/BE0012418TargetHumansInnate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624
Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I-like receptor 1Tumor necrosis factor receptor superfamily member 13C
go.drugbank.com/bio_entities/BE0018598TargetHumansB-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response
Polypeptides: Tumor necrosis factor receptor superfamily member 13CSynonyms: BAFF receptor, BLyS receptor 3Tumor necrosis factor receptor superfamily member 12A
go.drugbank.com/bio_entities/BE0020009TargetHumansReceptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins
Polypeptides: Tumor necrosis factor receptor superfamily member 12ASynonyms: Tweak-receptorAcetylcholine receptor subunit alpha-type acr-16
go.drugbank.com/bio_entities/BE0027703TargetCaenorhabditis elegansA subunit of the levamisole-insensitive nicotinic receptor.
Polypeptides: Acetylcholine receptor subunit alpha-type acr-16Azilsartan medoxomil
go.drugbank.com/drugs/DB08822ApprovedInvestigationalAzilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. … It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011.
Categories: Angiotensin II receptor antagonists, Angiotensin II Type 1 Receptor BlockersGefapixant
go.drugbank.com/drugs/DB15097Approvedor unexplained chronic cough (UCC) when no diagnosable cause for the cough can be determined. … [L48596] Gefapixant is a novel antagonist of the P2X3 receptor that works to reduce the cough reflex in patients with chronic cough.
Fruquintinib
go.drugbank.com/drugs/DB11679ApprovedInvestigationalThis approval is based on favorable results obtained from the FRESCO and FRESCO-2 trials, where an increase in overall survival rate was observed in both trials.[L48791] … anti-VEGF therapy, and, if RAS wild-type and medically appropriate, an anti-EGFR therapy.
Categories: Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors