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Displaying results 2421 - 2430 of 10000 in total
  1. Drug

    Amcipatricin

    go.drugbank.com/drugs/DB12333
    Investigational

    SPK-843 doses of higher than 1.0 mg/kg of body weight exhibit no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone … ) and liposomal amphotericin B.

  2. Drug

    Ledipasvir

    go.drugbank.com/drugs/DB09027
    Approved

    Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … therapy option in combination with [sofosbuvir] for the treatment of HCV genotypes 1a, 1b, 4, 5, and 6 [L852].

    Mixtures: HARVONI 90 MG/400 MG FILM KAPLI TABLET, 84 ADET, HARVONI 90 MG/400 MG FILM KAPLI TABLET, 28 ADETCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  3. Pathway

    Phenylketonuria

    smpdb.ca/view/SMP0125602
    Disease

    Phenylketonuria, also called Folling disease, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder that affects the proper processing of phenylalanine caused by a defective phenylalanine hydroxylase. Phenylalanine ...

    Drugs: Pyridoxal phosphate · Phenylalanine · L-Glutamine · Adenosine phosphate · Tyrosine · Glutamic acid +17 more
    Enzymes: Y+L amino acid transporter 1, Y+L amino acid transporter 2
  4. Target

    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

    go.drugbank.com/bio_entities/BE0000443
    EnzymeTargetHumans

    Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed:10518789). … D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR) (PubMed:10518789, PubMed:10566658, PubMed:12050193, PubMed:22862690, PubMed:9486994).

    Polypeptides: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialSynonyms: 25-OHD-1 alpha-hydroxylase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
  5. Drug

    Ergocalciferol

    go.drugbank.com/drugs/DB00153
    ApprovedInvestigationalNutraceutical

    [T580] Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at … Ergocalciferol is an inactivated vitamin D analog.[A177526] It is synthesized by some plants in the presence of UVB light.

    Synonyms: Vitamin D 2, Vitamin D-2Mixtures: Calcium Mg and Zn Capsules With Vitamin D, Cal/mag 2:1 With D
  6. Drug

    Troleandomycin

    go.drugbank.com/drugs/DB13179
    Approved

    A macrolide antibiotic that is similar to erythromycin.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
  7. Drug

    Icodextrin

    go.drugbank.com/drugs/DB00702
    ApprovedInvestigational

    It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.

    Mixtures: EXTRANEFROL PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML ÇİFTLİ, EXTRANEFROL PERİTON DİYALİZ ÇÖZELTİSİ, 2500 ML TEKLİCategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Nifurtimox

    go.drugbank.com/drugs/DB11820
    ApprovedInvestigational

    Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. … [L15366] Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of Chagas disease.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Meningococcal polysaccharide vaccine group A

    go.drugbank.com/drugs/DB13889
    ApprovedInvestigational

    *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. … It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup A.

    Mixtures: MENCEVAX ACWY 0,5 ML SC ENJEKSİYON İÇİN LİYOFİLİZE TOZ İÇEREN ÇOK DOZLU FLAKON, 50 ADET, MENACTRA 0,5 ML IM ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 5 ADETSynonyms: Neisseria meningitidis group A polysaccharide antigen, A, Meningococcal group A polysaccharide
  10. Drug

    Acetate

    go.drugbank.com/drugs/DB14511
    Investigational

    Synonyms: Acetate ion (1-), Acetic acid, ion(1-)Mixtures: Trinatal Rx 1, NUTRIFLEX LIPID PLUS INFUZYONLUK EMULSIYON, 2500 ML