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Platelet-derived growth factor receptor beta
go.drugbank.com/bio_entities/BE0000205TargetHumansReceptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1.
Polypeptides: Platelet-derived growth factor receptor betaSynonyms: Beta platelet-derived growth factor receptor, Platelet-derived growth factor receptor 1Neuronal acetylcholine receptor subunit alpha-10
go.drugbank.com/bio_entities/BE0000411TargetHumansThis may protect against acoustic trauma. May also regulate keratinocyte adhesion (By similarity) … The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane.
Polypeptides: Neuronal acetylcholine receptor subunit alpha-10Synonyms: Nicotinic acetylcholine receptor subunit alpha-10Putative gonadotropin-releasing hormone II receptor
go.drugbank.com/bio_entities/BE0000472TargetHumansPutative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional
Polypeptides: Putative gonadotropin-releasing hormone II receptorSynonyms: GnRH II receptor, Type II GnRH receptorRetinoic acid receptor responder protein 1
go.drugbank.com/bio_entities/BE0000653TargetHumansInhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle
Polypeptides: Retinoic acid receptor responder protein 1Anti-Muellerian hormone type-2 receptor
go.drugbank.com/bio_entities/BE0000675TargetHumansReceptor for anti-Muellerian hormone … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Polypeptides: Anti-Muellerian hormone type-2 receptorSynonyms: AMH type II receptor, MIS type II receptorNeuronal acetylcholine receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0000738TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-2Synonyms: Nicotinic acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit alpha-4
go.drugbank.com/bio_entities/BE0000849TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-4C-C chemokine receptor type 9
go.drugbank.com/bio_entities/BE0002463TargetHumansReceptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level
Polypeptides: C-C chemokine receptor type 9Synonyms: G protein-coupled receptor 28Baculoviral IAP repeat-containing protein 5
go.drugbank.com/bio_entities/BE0003408TargetHumansMay counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). … May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398).
Polypeptides: Baculoviral IAP repeat-containing protein 5Neuronal acetylcholine receptor subunit alpha-3
go.drugbank.com/bio_entities/BE0003585TargetHumansCHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:31488329).
Polypeptides: Neuronal acetylcholine receptor subunit alpha-3