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Bexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigationalBexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is ...
Synonyms: D-glucitol, 1,5-anhydro-1-C-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1s)-Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesDronabinol
go.drugbank.com/drugs/DB00470ApprovedIllicitInvestigationalDue to its evidence as an appetite stimulant and an anti-nauseant, Dronabinol is approved for use in anorexia associated with weight loss in patients with AIDS and for the treatment of nausea and vomiting … Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two most abundant cannabinoids found naturally in the resin of the marijuana plant, both of which are pharmacologically active due to their interaction
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,d)pyran-1-olMethyl undecenoyl leucinate
go.drugbank.com/drugs/DB11272ApprovedMethyl undecenoyl leucinate is an active ingredient in whitening creams. … It is an α-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression of various melanogenic genes.
Encorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalapproved encorafenib and [binimetinib] (BRAFTOVI and MEKTOVI, Array BioPharma Inc.) in combination for patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesIoversol
go.drugbank.com/drugs/DB09134ApprovedInvestigational[L41780] Ioversol is a highly hydrophilic agent considered to be generally safe[L41790]; however, serious adverse reactions have been reported due to the inadvertent intrathecal administration of ioversol
Boron
go.drugbank.com/drugs/DB11203ApprovedInvestigationalNatural boron exists in 2 stable isotopes however pure boron is hard to prepare due to contamination by different elements. … Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table.
Mixtures: Calcium Folic Acid Plus D ChewableIbrexafungerp
go.drugbank.com/drugs/DB12471Approved[A235384] Ibrexafungerp is orally bioavailable compared to the echinocandins [caspofungin], [micafungin], and [anidulafungin]; which can only be administered parenterally.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: enfumafungin derivative B-(1,3)-D-glucan synthestis inhibitorEbola Zaire vaccine (live, attenuated)
go.drugbank.com/drugs/DB15595ApprovedInvestigational[L10866] In non-human primate clinical trials, the vaccine was effective in inducing an immune response against the Ebola viruses. … Ervebo consists of an envelope glycoprotein of the Zaire ebolavirus (Kikwit 1995 strain) fused into a vesicular stomatitis virus (VSV) backbone.
Suprofen
go.drugbank.com/drugs/DB00870ApprovedWithdrawnAn ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsSynonyms: p-2-thenoylhydratropic acid, (±)-2-(p-(2-thenoyl)phenyl)propionic acidHu-PHEC Liver
go.drugbank.com/drugs/DB18347ExperimentalHu-PHEC Liver is an adult hemogenic endothelial cells.
Synonyms: Hu-PHEC Liver