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Mirabegron
go.drugbank.com/drugs/DB08893ApprovedInvestigational[L32853] Mirabegron first received FDA approval in 2012, under the brand name Myrbetriq, for the treatment of adults with overactive bladder. … Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence.
Products: MYRBETRIC® 50 MG TABLETAS DE LIBERACION PROLONGADA, MYRBETRIC® 25 MG TABLETAS DE LIBERACION PROLONGADAMavacamten
go.drugbank.com/drugs/DB14921ApprovedInvestigationalIt received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans. … Mavacamten is a myosin inhibitor indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM).
Products: CAMZYOS® 2.5MG CAPSULAS DURAS DE LIBERACIÓN INMEDIATA.Bosutinib
go.drugbank.com/drugs/DB06616ApprovedInvestigationalPhiladelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR-ABL fusion protein. … Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: BOSUTINIB DR. REDDY?SPhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approvedPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.
Categories: UGT1A1 Substrates with a Narrow Therapeutic Index, UGT1A6 Substrates with a Narrow Therapeutic IndexProducts: Epilan-D 100 mg - Tabletten, Epilan-D 50 mg/ml - AmpullenCefalotin
go.drugbank.com/drugs/DB00456ApprovedVet approvedWithdrawnCefalotin is a cephalosporin antibiotic.
Products: CEFALOTINA 1 GRUPO DE MEDICAMENTOS. INYECTABLE, CEFALOTINA 1G POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLEZoledronic acid
go.drugbank.com/drugs/DB00399ApprovedInvestigational[A203120] Zoledronic acid was granted FDA approval on 20 August 2001.[L13712] … Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid].
Salts: Zoledronate D,L-Lysine MonohydrateProducts: ACIDO ZOLEDRONICO SUN PHARMACEUTICAL INDUSTRIES EUROPE BV, ASZORA TRIO CA+D3 4MG/100Doxylamine
go.drugbank.com/drugs/DB00366ApprovedInvestigationalVet approvedHistamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Mixtures: Wal Tussin DM Max Nighttime Wal Tussin DM Max, Tussin DMProducts: Dg Health Sleep AidSorafenib
go.drugbank.com/drugs/DB00398ApprovedInvestigationalSorafenib is a bi-aryl urea and an oral multikinase inhibitor. … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also indicated to treat renal carcinoma and differentiated thyroid carcinoma
Categories: UGT1A9 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: SORAFENIB DR. REDDYSFlutamide
go.drugbank.com/drugs/DB00499ApprovedInvestigationalAn antiandrogen with about the same potency as cyproterone in rodent and canine species.
Products: ETACONIL DE 250 MG COMPRIMIDOS, FLUTAMIDE MYLAN GENERICSNabumetone
go.drugbank.com/drugs/DB00461Approved[label,A178903] The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. … Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).
Products: Relafen DS