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2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
go.drugbank.com/bio_entities/BE0000518TargetHumansPyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA
Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialA disintegrin and metalloproteinase with thrombospondin motifs 5
go.drugbank.com/bio_entities/BE0003730TargetHumansPlays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11Acamprosate
go.drugbank.com/drugs/DB00659ApprovedInvestigationalIt is a structural analogue of the neurotransmitter γ-aminobutyric acid (GABA). … It was first approved by the FDA in 2004 and initially marketed by Forest Laboratories.[L31783]
Synonyms: 3-Acetamido-1-propanesulfonic acid, N-AcetylhomotaurineProducts: CAMPRAL 333 MG ENTERIK TABLET, 84 ADETNeratinib
go.drugbank.com/drugs/DB11828ApprovedInvestigationalNeratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 奈拉替尼Tetrofosmin
go.drugbank.com/drugs/DB11180ApprovedTetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.[A7788] … It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines.
Mixtures: Tetrofosmin ROTOP 0,23 mg Kit für ein radioaktives ArzneimittelCategories: P-glycoprotein substratesPentastarch
go.drugbank.com/drugs/DB09111ApprovedWithdrawnWhen administered, pentastarch remains mainly in the circulatory system and hence, it is considered a plasma expander. … Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation.
Categories: Compounds used in a research, industrial, or household settingProducts: HESTAR-200Fosfomycin
go.drugbank.com/drugs/DB00828ApprovedInvestigational[A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring. … [A230348] Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated
Synonyms: L-cis-1,2-epoxypropylphosphonic acid, (2R-cis)-(3-Methyloxiranyl)phosphonic acidProducts: SOLUFOS® 500 MG, Fomicyt 40 mg/ml Pulver zur Herstellung einer InfusionslösungFerrous ascorbate
go.drugbank.com/drugs/DB14490ApprovedWithdrawnCategories: Compounds used in a research, industrial, or household settingSynonyms: Iron(2+) L-ascorbate, L-Ascorbic acid, iron complexPranlukast
go.drugbank.com/drugs/DB01411InvestigationalPranlukast is a cysteinyl leukotriene receptor-1 antagonist. … It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsProducts: PRANLUX 100 MG SAŞE, 30 SAŞE, PRANLUX 100 MG SAŞE, 90 SAŞEPotassium voltage-gated channel subfamily A member 1
go.drugbank.com/bio_entities/BE0000781TargetHumansPlays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (PubMed:19307729, PubMed:23903368 … Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception
Polypeptides: Potassium voltage-gated channel subfamily A member 1