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Displaying results 2551 - 2560 of 2674 in total
  1. Drug

    Ciltacabtagene autoleucel

    go.drugbank.com/drugs/DB16738
    ApprovedInvestigational

    [A245854] Carvykti was first approved by the FDA in February 2022 for the treatment of relapsed or refractory multiple myeloma in treatment-experienced patients.[L40744] … [L40739] Patient T-cells are reprogrammed with a transgene encoding a specific chimeric antigen receptor (CAR) which features two BCMA-targeting single-domain antibodies.

  2. Drug

    Elivaldogene autotemcel

    go.drugbank.com/drugs/DB16746
    Approved

    [L40298] In September 2022, Skysona was approved by the FDA.[L43247]

  3. Drug

    SYNB1020

    go.drugbank.com/drugs/DB17667
    Investigational

    It was initially designed to convert ammonia to L-arginine [A258838] and granted orphan designation by the FDA for the treatment of urea cycle disorders in August 2016;[L45988] however, the manufacturer

  4. Target

    Stabilin-2

    go.drugbank.com/bio_entities/BE0004948
    TargetHumans

    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). … Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature.

    Synonyms: Hyaluronan receptor for endocytosis, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
  5. Target

    Protein arginine N-methyltransferase 1

    go.drugbank.com/bio_entities/BE0004597
    TargetHumans

    May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator

    Synonyms: Interferon receptor 1-bound protein 4
  6. Target

    Integrin alpha-5

    go.drugbank.com/bio_entities/BE0008988
    TargetHumans

    ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). … ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).

    Synonyms: Fibronectin receptor subunit alpha
  7. Target

    Ephrin-B2

    go.drugbank.com/bio_entities/BE0010647
    TargetHumans

    Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Synonyms: EPH-related receptor tyrosine kinase ligand 5Function: ephrin receptor binding
  8. Drug

    CTS-21166

    go.drugbank.com/drugs/DB06073
    Investigational

    CTS-21166 is the only BACE1 inhibitor that has passed Phase I clinical trial thus far.

  9. Drug

    Loprazolam

    go.drugbank.com/drugs/DB13643
    Experimental

    It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.

  10. Target

    C-type lectin domain family 12 member A

    go.drugbank.com/bio_entities/BE0010945
    TargetHumans

    Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).

    Synonyms: Killer cell C-type lectin-like receptor L1, Myeloid inhibitory C-type lectin-like receptorFunction: pattern recognition receptor activity