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Adiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member IRevefenacin
go.drugbank.com/drugs/DB11855ApprovedInvestigational[A40025] From the LAMA group, revefenacin is the first once-daily nebulized LAMA treatment.[A40026] It was developed by Theravance Biopharma and FDA approved on November 9, 2018.[L4818] … The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic clearance and minimizing of the systemically mediated adverse reactions.
Metastatic Malignant Neoplasm to the Leptomeninges
go.drugbank.com/conditions/DBCOND0057483Drugs: CytarabineSynonyms: Metastatic Malignant Neoplasm in the LeptomeningesCAI-1 autoinducer synthase
go.drugbank.com/bio_entities/BE0004287TargetVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.
Polypeptides: CAI-1 autoinducer synthaseTeduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine).
Synonyms: Glucagon-like peptide II (2-glycine) (human)Categories: Compounds used in a research, industrial, or household setting, Alimentary Tract and MetabolismOpioid Dependence
go.drugbank.com/conditions/DBCOND0030983Synonyms: [X]Mental and behavioral disorders due to use of opioids: dependence syndrome, [X]Mental and behavioural disorders due to use of opioids: dependence syndromeBrexucabtagene autoleucel
go.drugbank.com/drugs/DB15699ApprovedInvestigationalMantle cell lymphoma (MCL) is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. … [L15148] Brexucabtagene autoleucel was granted full approval by the FDA on July 24, 2020 for the treatment of MCL and acute lymphoblastic leukemia (ALL), and is currently available through Kite Pharma
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic cell and gene therapyNiraparib
go.drugbank.com/drugs/DB11793ApprovedInvestigationalNiraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. … [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health Canada on June 27, 2019.
Categories: niraparib and abiraterone, Antineoplastic and Immunomodulating AgentsEteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigational[A244930] It is caused by loss-of-function mutations in the DMD gene coding for dystrophin, an essential protein involved in maintaining the structural integrity and function of muscle fibres. … It consists of a six-membered morpholino ring replacing the five-membered ribofuranosyl rings found in natural DNA and RNA.
Synonyms: N-dimethylphosphonamidate) RNA, dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonyl)-1-piperazinyl)-N,Categories: Nucleic Acids, Nucleotides, and Nucleosides, Compounds used in a research, industrial, or household settingIdebenone
go.drugbank.com/drugs/DB09081ApprovedInvestigationalIt is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada. … Due to its biochemical mode of action, it's thought that idebenone may re-activate viable-but-inactive retinal ganglion cells (RGCs) in LHON patients [L885].
Categories: Compounds used in a research, industrial, or household setting, Enzymes and Coenzymes