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Enprofylline
go.drugbank.com/drugs/DB00824ApprovedWithdrawnEnprofylline is a derivative of theophylline which shares bronchodilator properties.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 3-n-propylxanthine, 3-propylxanthineLevomenthol
go.drugbank.com/drugs/DB00825ApprovedInvestigationalMenthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
Mixtures: MOVIDOL® U., KAMFOLIN 150 MG/G+100 MG/G MERHEM, 50 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNatamycin
go.drugbank.com/drugs/DB00826ApprovedInvestigationalAmphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
International brands: N-MycinProducts: NATACYN ® 5% SUSPENSION OFTALMICA ESTERIL, FUKRICIN 5%Cefaclor
go.drugbank.com/drugs/DB00833ApprovedInvestigationalSemisynthetic, broad-spectrum antibiotic derivative of cephalexin.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acidBrompheniramine
go.drugbank.com/drugs/DB00835ApprovedHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Mixtures: Bio T Pres-B, J-tan D PdCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingLoperamide
go.drugbank.com/drugs/DB00836ApprovedInvestigational[A251610] Loperamide has a chemical structure that is similar to diphenoxylate and haloperidol;[A6249] however, loperamide works on mu (μ)-opioid receptors to mediate its pharmacological actions. … [A251610] It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors on intestinal muscles to decrease intestinal motility and electrolyte loss.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: A D, Imodium A-DFlurandrenolide
go.drugbank.com/drugs/DB00846ApprovedA corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Drenison Tape M 170 4mcg Sq CmMethylphenobarbital
go.drugbank.com/drugs/DB00849ApprovedA barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 5-ethyl-1-methyl-5-phenylbarbituric acid, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trioneDacarbazine
go.drugbank.com/drugs/DB00851ApprovedInvestigationalAn antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic IndexSynonyms: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamideTemozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigationalIt is currently marketed under the trademark TEMODAR® by Merck.[L32033] … [A229853, A229888, A229923, L32033] Following initial hydrolysis, further reactions liberate a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesSynonyms: 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one