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NV-5138
go.drugbank.com/drugs/DB19180InvestigationalNV-5138 is under investigation in clinical trial NCT06235905 (Open-label of SPN-820 in Adults With Major Depressive Disorder).
Setogepram
go.drugbank.com/drugs/DB15447InvestigationalSetogepram is under investigation in clinical trial NCT03184584 (Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome).
YCT-529
go.drugbank.com/drugs/DB21748InvestigationalYCT-529 is under investigation in clinical trial NCT06542237 (Open Label, Repeat Dose Study Evaluating YCT-529 in Healthy Males).
Polihexanide
go.drugbank.com/drugs/DB12277ApprovedInvestigational[A1351,A273908] Polihexanide is approved in Europe under the name Akantior for the treatment of _Acanthamoeba_ keratitis, an ocular infection caused by the _Acanthamoeba_ parasite.
Parathyroid hormone
go.drugbank.com/drugs/DB05829ApprovedInvestigationalPreotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures and is marketed in Europe by Nycomed.
Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalThe US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383]
Aceclidine
go.drugbank.com/drugs/DB13262ApprovedAceclidine is a cholinergic muscarinic agonist which began marketing in Europe in the 1970s for the treatment of glaucoma.
Chondroitin sulfate
go.drugbank.com/drugs/DB09301ApprovedInvestigationalNutraceutical[A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066]
Ketotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigational[L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy.
Carbocisteine
go.drugbank.com/drugs/DB04339ApprovedInvestigational[A230993] Carbocisteine is currently not FDA or Health Canada approved, but is approved for use in Asia, Europe, and South America.