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Serine/threonine-protein kinase DCLK3
go.drugbank.com/bio_entities/BE0009431TargetHumansSynonyms: Doublecortin-like and CAM kinase-like 3Mifepristone
go.drugbank.com/drugs/DB00834ApprovedInvestigationalIts inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. … Mifepristone is a progestational and glucocorticoid hormone antagonist.
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemSarafloxacin
go.drugbank.com/drugs/DB11491ApprovedVet approvedWithdrawnSarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada.
Human varicella-zoster immune globulin
go.drugbank.com/drugs/DB11621ApprovedInvestigationalIt is prepared from pools of healthy human donors' plasma via anion-exchange column chromatography and was approved in 2012 under the name VariZIG to reduce the disease severity in high-risk patients who … lack evidence of immunity to varicella and for whom varicella vaccine is contraindicated.
Categories: Fluids and Secretions, Amino Acids, Peptides, and ProteinsDNA damage-inducible transcript 4 protein
go.drugbank.com/bio_entities/BE0003445TargetHumansIts role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). … Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.
Synonyms: Protein regulated in development and DNA damage response 1Caspase-4
go.drugbank.com/bio_entities/BE0009964TargetHumansCleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412 … The non-canonical inflammasome is required for innate immunity to cytosolic, but not vacuolar, bacteria (By similarity).
Synonyms: ICE and Ced-3 homolog 2Measles virus vaccine live attenuated
go.drugbank.com/drugs/DB10315ApprovedInvestigationalThe vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture.
Mixtures: MEASLES AND RUBELLA VIRUS VACCINE LIVE, SII Measles and Rubella Virus Vaccine live.Attenuated(Freeze-Dried) 1 doseAcid Cholesteryl Ester Hydrolase Deficiency, Wolman Type
go.drugbank.com/conditions/DBCOND0076044Drugs: Sebelipase alfaSynonyms: Deficiency of cholesterol esterase and triacylglycerol lipaseTriple-Negative Breast Cancer
go.drugbank.com/conditions/DBCOND0068542Drugs: AtezolizumabSynonyms: Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative