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Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126504Drug actionLidocaine is a local anesthetic used in a wide variety of superficial and invasive procedures. It can be found under the brand names Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2FET F-18
go.drugbank.com/drugs/DB15405InvestigationalFET F-18 is under investigation in clinical trial NCT01756352 (FET-PET for Evaluation of Response of Recurrent GBM to Avastin).
Categories: fluoroethyl-L-tyrosine (18F)Synonyms: O-(2-FLUOROETHYL)-L-TYROSINE F-18, O-18F-fluoroethyl-L-tyrosineBrimonidine
go.drugbank.com/drugs/DB00484ApprovedInvestigational[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. … [A179002] Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists.
Synonyms: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxalineMixtures: Tim-Brim-Dor-Lat, BRIMONIDINA E TIMOLOLO EGInfluenza B virus B/Singapore/INFTT-16-0610/2016 antigen (MDCK cell derived, propiolactone inactivated)
go.drugbank.com/drugs/DB15507ApprovedWithdrawnA seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3.
Mixtures: Flucelvax Quadrivalent (pre-filled Syringe), Flucelvax Quadrivalent (pre-filled Syringe)Synonyms: Influenza B virus B/Singapore/INFTT-16-0610/2016 antigen (MDCK cell derived, propiolactone inactivated)Baclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigationalBaclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.
Synonyms: 4-Amino-3-(4-chlorophenyl)butyric acid, DL-4-Amino-3-p-chlorophenylbutanoic acidMixtures: Innoprax-5DaxibotulinumtoxinA
go.drugbank.com/drugs/DB17929ApprovedInvestigationalIt is a botulinum toxin without accessory proteins purified from the bacterium _Clostridium botulinum_ type A,[L47840] the gram-positive anaerobic bacterium primarily present in soil. … [L47870] DAXI or DAXXIFY, a product of daxibotulinumtoxinA, incorporates RTP004, a proprietary synthetic stabilizing peptide for enhanced product stability.[A261080, A261085]
Categories: Botulinum Toxins, Type ANOP-1A
go.drugbank.com/drugs/DB15208InvestigationalNOP-1A is under investigation in clinical trial NCT01198197 (PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A).
Synonyms: NOP-1AFluorine F-18
go.drugbank.com/drugs/DB13134InvestigationalFluorine-18 is under investigation in clinical trial NCT00870974 (A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions).
Synonyms: Fluorine F-18Fludeoxyglucose
go.drugbank.com/drugs/DB15107InvestigationalFludeoxyglucose is under investigation in clinical trial NCT03262389 (Comparison of F-18 FDG and C-11 Acetate PET in Multiple Myeloma).
Amiodarone Action Pathway (New)
smpdb.ca/view/SMP0122646Drug actionAmiodarone is a class III antiarrhythmic drug used for treating ventricular arrythmias. It is administered orally or intravenously. Amiodarone targets the cardiac myocytes where it blocks the inward rectifying potassium channels. This po...
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2