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Ropinirole
go.drugbank.com/drugs/DB00268ApprovedInvestigationalRopinirole, also known as _ReQuip_, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], [A174547]. … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: ROPINIROL-NEURAX 5 MG, ROPINIROL AL 5 MG FILMTABLInsulin glargine
go.drugbank.com/drugs/DB00047ApprovedInvestigationalAs of 2015, insulin glargine was reformulated by Sanofi as the product Toujeo in an extra-concentrated form containing 300IU/mL (compared to 100IU/mL contained in Lantus). … If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening
International brands: Lantus RMixtures: SOLİQUA SOLOSTAR 100 U/ML + 50 MCG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 5 KALEM, SOLİQUA SOLOSTAR 100 U/ML + 33 MCG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 5 KALEMPosaconazole
go.drugbank.com/drugs/DB01263ApprovedInvestigationalVet approvedPosaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: POSACONAZOLO EG, POSACONAZOLO EG STADAFluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalFluticasone propionate was first approved in 1990[L5962]. … Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label].
Mixtures: FLUTIFORM® 50 MCG / 5 MCG, FLUTIFORM® 50 MCG / 5 MCGCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesFusidic acid
go.drugbank.com/drugs/DB02703ApprovedInvestigationalAn antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis. … It is often used topically in creams and eyedrops but is available in systemic formulations including tablets and injections.
Mixtures: Fusicutan 20 mg/g + 1 mg/g Creme, FUCICORT 20 MG/G + 1 MG/G KREM, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsRupatadine
go.drugbank.com/drugs/DB11614ApprovedInvestigationalRupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria … It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and liquid formulation for pediatric use.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: RUPATADINA EG, RUPAFIN® 10 MGTryptophan 5-hydroxylase 2
go.drugbank.com/bio_entities/BE0000080EnzymeTargetHumansNeuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin
Polypeptides: Tryptophan 5-hydroxylase 2Synonyms: Tryptophan 5-monooxygenase 25-hydroxytryptamine receptor 4
go.drugbank.com/bio_entities/BE0000084TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed
Polypeptides: 5-hydroxytryptamine receptor 4Synonyms: 5-HT4, 5-HT-45-hydroxytryptamine receptor 2B
go.drugbank.com/bio_entities/BE0000393TargetHumansPlays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600).
Polypeptides: 5-hydroxytryptamine receptor 2BSynonyms: 5-HT2B, 5-HT-2B5-hydroxytryptamine receptor 1F
go.drugbank.com/bio_entities/BE0000460TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:21422162, PubMed:34239069, PubMed:8380639, PubMed:8384716).
Polypeptides: 5-hydroxytryptamine receptor 1FSynonyms: 5-HT1F, 5-HT-1F