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Displaying results 2781 - 2790 of 10000 in total
  1. Drug

    Quizartinib

    go.drugbank.com/drugs/DB12874
    ApprovedInvestigational

    [A260641] Quizartinib was approved by the FDA in July 2023 and developed under the brand name VANFLYTA by Daiichi Sankyo. … Quizartinib is an oral and potent fms-like tyrosine kinase 3 (FLT3) inhibitor and it is the first drug developed specifically targeting FLT3, as other agents with FLT3 inhibition activities were investigated

    Categories: Antineoplastic and Immunomodulating AgentsSynonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
  2. Drug

    Hetacillin

    go.drugbank.com/drugs/DB00739
    ApprovedVet approvedWithdrawn

    Hetacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. … Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.

  3. Drug

    Fluticasone

    go.drugbank.com/drugs/DB13867
    ApprovedInvestigationalWithdrawn

    [DB00588] was first approved in 1990[L5962] and [DB08906] was approved in 2007[L5965]. … Fluticasone is a synthetic glucocorticoid available as 2 esters, [DB08906] and [DB00588][F4355,F4358,F4361,F4364][FDA Label].

    Mixtures: Fludalt DUO 250/50mcg Inhalation Powder Hard CapsulesCategories: formoterol and fluticasone, salmeterol and fluticasone
  4. Target

    Metal cation symporter ZIP8

    go.drugbank.com/bio_entities/BE0009901
    TransporterHumans

    Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization (PubMed:29927450). … Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development

    Synonyms: Zrt- and Irt-like protein 8, BCG-induced integral membrane protein in monocyte clone 103 protein
  5. Drug

    Sonesitatug Vedotin

    go.drugbank.com/drugs/DB18619
    Investigational

    CMG901 is an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload.

    Synonyms: an anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload
  6. Drug

    Trolamine

    go.drugbank.com/drugs/DB13747
    ApprovedInvestigational

    It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products. … Trolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats [A27174].

    Mixtures: RUNYI MIAOJIE Hand sanitizer, RUNYI MIAOJIE Hand sanitizerCategories: Preparations for Treatment of Wounds and Ulcers
  7. Drug

    Sorafenib

    go.drugbank.com/drugs/DB00398
    ApprovedInvestigational

    Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also indicated to treat renal carcinoma and differentiated thyroid carcinoma

    Synonyms: N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea, 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamideCategories: Antineoplastic and Immunomodulating Agents
  8. Drug

    Lumateperone

    go.drugbank.com/drugs/DB06077
    ApprovedInvestigational

    [A189093] Further, not only is the new antipsychotic selective for dopamine (D2) receptors in the mesolimbic and mesocortical brain regions, but it also has minimal off-target activity. … [A189093,A189174] The data so far indicates that lumateperone can alleviate both positive and negative symptoms of schizophrenia.

  9. Drug

    Misoprostol

    go.drugbank.com/drugs/DB00929
    ApprovedInvestigational

    [L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the … strength and frequency of contractions and decrease cervical tone.

    Mixtures: Diclofenac Sodium and Misoprostol, Diclofenac Sodium and MisoprostolCategories: naproxen and misoprostol, Alimentary Tract and Metabolism
  10. Indication

    Proliferative Diabetic Retinopathy (PDR)

    go.drugbank.com/conditions/DBCOND0056889
    Drugs: Ranibizumab
    Synonyms: Retinopathy co-occurrent and due to diabetes mellitus, Proliferative retinopathy co-occurrent and due to diabetes mellitus