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Phosphatidylethanolamine Biosynthesis PE(18:3(9Z,12Z,15Z)/15:0)
smpdb.ca/view/SMP0015347MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
Drugs: Choline · Serine · Phosphatidyl serine · ATP · Cytidine-5'-Triphosphate · Ethanolamine +1 moreAcylcarnitine (5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoylcarnitine
smpdb.ca/view/SMP0123544Metabolic(5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoyl-CoA reacts with L-carnitine to form (5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoylcarnitine
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreVernakalant
go.drugbank.com/drugs/DB06217ApprovedInvestigationalVernakalant was developed by Cardiome Pharma as as an antiarrhythmic drug intended for rapid conversion of atrial fibrillation to sinus rhythm. … It acts as an atypical class III antiarrhythmic drug that potentiates its effect in higher heart rates.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsBlonanserin
go.drugbank.com/drugs/DB09223InvestigationalIt offers improved tolerability as it lacks side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. … Blonanserin is an atypical antipsychotic approved in Japan in January, 2008.
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesPhosphatidylcholine Biosynthesis PC(18:3(9Z,12Z,15Z)/15:0)
smpdb.ca/view/SMP0014507MetabolicPhosphatidylcholines (PC) are a class of phospholipids that incorporate a phosphocholine headgroup into a diacylglycerol backbone. They are the most abundant phospholipid in eukaryotic cell membranes and has both structural and signallin...
Drugs: Ademetionine · Choline · Phosphatidyl serine · ATP · Cytidine-5'-Triphosphate · N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium +2 moreFostemsavir
go.drugbank.com/drugs/DB11796ApprovedInvestigational[L14867] The discovery of gp120 as a potential target of interest in the treatment of HIV-1 infection is relatively recent, and was born out of a desire to find alternative target proteins (i.e. mechanistically … Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRhubarb
go.drugbank.com/drugs/DB10651ApprovedRhubarb allergenic extract is used in allergenic testing.
Mixtures: ORALDIN ÇÖZELTI ,10 ML-1 ŞIŞE, PIRALDYNE ORAL SOLUSYON 10 MLRevumenib
go.drugbank.com/drugs/DB18515ApprovedInvestigationalAbnormal gene rearrangements at chromosome locus 11q23, called KMT2A rearrangements or translocations, are present in 5%-10% of patients with acute leukemias and are the sole genetic aberration found in … [A264688] Revumenib is an oral small molecule menin inhibitor that prevents the interaction between menin and aberrant KMT2A.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsTelisotuzumab vedotin
go.drugbank.com/drugs/DB15104ApprovedInvestigationalTelisotuzumab vedotin is an antibody-drug conjugate comprising [telisotuzumab], a c-Met-directed humanized IgG1κ monoclonal antibody, conjugated to monomethyl auristatin E (MMAE), a small molecule microtubule-disrupting … agent, via a protease-cleavable valine-citrulline linker.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsAmivantamab
go.drugbank.com/drugs/DB16695ApprovedInvestigational[A235103,A235123] Patients with NSCLC with exon 20 insertion mutations in EGFR do not respond to tyrosine kinase inhibitors, and were generally treated with platinum-based therapy. … Amivantamab, also known as JNJ-61186372, is an anti-EGFR-MET bispecific antibody, derived from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or metastatic