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Displaying results 2831 - 2840 of 10000 in total
  1. Drug

    Vosoritide

    go.drugbank.com/drugs/DB11928
    ApprovedInvestigational

    of a condition like achondroplasia. … of a peptidase-resistant formulation has allowed for its use as a viable treatment option in achondroplasia.

    Categories: C-type Natriuretic Peptide Analog
  2. Drug

    Pertuzumab

    go.drugbank.com/drugs/DB06366
    ApprovedInvestigational

    Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). … Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.

    Mixtures: PHESGO® 600MG/600MG, PHESGO® 600MG/600MGCategories: Receptor, ErbB-2, antagonists & inhibitors, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  3. Drug

    Ezetimibe

    go.drugbank.com/drugs/DB00973
    ApprovedInvestigational

    Ezetimibe is a lipid-lowering compound that inhibits intestinal cholesterol and phytosterol absorption. … [L11347] Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick

    Mixtures: TIAZOMET ® A 40/10 TABLETAS, EZETIMIBE E SIMVASTATINA EGCategories: P-glycoprotein substrates, Cytochrome P-450 CYP2C8 Inhibitors
  4. Drug

    Dusigitumab

    go.drugbank.com/drugs/DB12363
    Investigational

    Dusigitumab has been used in trials studying the treatment of Cancer, Advanced Solid Malignancies, Unresectable or Metastatic Hepatocellular Carcinoma (HCC), and Hormone-sensitive, HER-2 Negative Metastatic

  5. Drug

    Ritonavir

    go.drugbank.com/drugs/DB00503
    ApprovedInvestigational

    Any HCV/HIV-1 co-infected patients treated with ritonavir-containing combination therapies should also be on a suppressive antiretroviral drug regimen to reduce the risk of HIV-1 protease inhibitor drug … While ritonavir is not an active antiviral agent against hepatitis C virus (HCV) infection, it is added in combination therapies indicated for the treatment of HCV infections as a booster.

    Mixtures: LOPINAVIR E RITONAVIR MYLAN, LOPINAVIR E RITONAVIR MYLANCategories: P-glycoprotein inducers, P-glycoprotein inhibitors
  6. Pathway

    Acebutolol Action Pathway

    smpdb.ca/view/SMP0000296
    Drug action

    Acebutolol (also known as Sectral or Prent) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats (arrhythmias). Acebutolol al...

    Drugs: ATP · Acebutolol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  7. Pathway

    Penbutolol Action Pathway

    smpdb.ca/view/SMP0000305
    Drug action

    Penbutolol (also known as Levatol or Levatolol) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Penbutolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the b...

    Drugs: ATP · Potassium cation · Penbutolol · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  8. Pathway

    Lidocaine (Antiarrhythmic) Action Pathway

    smpdb.ca/view/SMP0000328
    Drug action

    This pathway illustrates the lidocaine targets involved in antiarrhythmic therapy. Contractile activity of cardiac myocytes is elicited via action potentials mediated by a number of ion channel proteins. During rest, or diastole, cells m...

    Drugs: NADH · ATP · Lidocaine · Potassium cation · Calcium · Mesoheme +1 more
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  9. Pathway

    Mexiletine Action Pathway

    smpdb.ca/view/SMP0000329
    Drug action

    This pathway illustrates the mexiletine targets involved in antiarrhythmic therapy. Contractile activity of cardiac myocytes is elicited via action potentials mediated by a number of ion channel proteins. During rest, or diastole, cells ...

    Drugs: ATP · Mexiletine · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  10. Pathway

    Carvedilol Action Pathway

    smpdb.ca/view/SMP0000367
    Drug action

    Carvedilol, trade name Coreg, is a nonselective beta-blocker that blocks both alpha and beta receptors of the heart and blood vessels. It is prescribed to treat hypertension, stable angina pectoris and congestive heart failure. Carvedilo...

    Drugs: ATP · Carvedilol · Potassium cation · Calcium
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2