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RUS 3108
go.drugbank.com/drugs/DB05911ExperimentalRUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories. … The drug’s Phase I clinical trials have been initiated in Europe to assess safety of the drug compound in healthy volunteers.
Disopyramide Cardiac Action Pathway
smpdb.ca/view/SMP0126247Drug actionSome side effects of using disopyramide may include dizziness, difficulty urinating, dry mouth, and nausea.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseMexiletine Action Pathway (New)
smpdb.ca/view/SMP0126263Drug actionMexiletine is a class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Mexiletine (INN) (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal h...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseProcainamide Action Pathway (New)
smpdb.ca/view/SMP0126265Drug actionThe main antidysrythmIc effect is mediated through the sodium channel blockage though. … Some side effects of using procainamide may include cardiac toxicity, bradycardia, hypotension, drug-induced lupus erythematosus-like syndrome, and blood dyscrasias.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseMoricizine Action Pathway
smpdb.ca/view/SMP0126950Drug actionMoricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. This results in a slowed atrioventricular nodal and His-Pu...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseMolsidomine
go.drugbank.com/drugs/DB09282ApprovedWithdrawnMolsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. … Interestingly, it is being studied as being a preventive measure in cerebral infarction [A31932].
Categories: Heterocyclic Compounds, 1-RingProducts: MOLSIDOMIN 2 HEUMANN, MOLSIDOMIN 4 HEUMANNRopivacaine
go.drugbank.com/drugs/DB00296ApprovedInvestigationalRopivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. … It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.[L42140]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: (S)-(−)-1-propyl-2',6'-pipecoloxylidide, L-N-n-propylpipecolic acid-2,6-xylidideAcetophenazine
go.drugbank.com/drugs/DB01063ApprovedAcetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking.
Categories: Heterocyclic Compounds, 3-RingRuplizumab
go.drugbank.com/drugs/DB06475InvestigationalRuplizumab is a humanized monoclonal antibody used as an immunosuppressive drug and is a component of Antova.
Eluxadoline
go.drugbank.com/drugs/DB09272ApprovedInvestigationalMarketed under the tradename Viberzi (FDA), eluxadoline is an antimotility agent that decreases bowel contractions, inhibits colonic transit, and reduces fluid/ion secretion resulting in improved symptoms … Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid