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Amiodarone Action Pathway (New)
smpdb.ca/view/SMP0122646Drug actionAmiodarone may have adverse effects such as thyrotoxicosis or hypothyroidism, tremor, uncontrollable and unusual movement of the body, dizziness, headache, nausea and vomiting, constipation, blurred vision
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseDofetilide Action Pathway
smpdb.ca/view/SMP0126189Drug actionDofetilide, brand name tikosyn, is a class III antiarrhythmic agent. This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Dofetilide increases the monophasic a...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseAjmaline Action Pathway
smpdb.ca/view/SMP0126271Drug actionSome side effects of using ajmaline may include warm flushes, tingling skin, vertigo, and eye twitches. … It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferasePropafenone Action Pathway
smpdb.ca/view/SMP0126275Drug actionSome side effects of using propafenone may include dizziness, dry mouth, headache, and nausea.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseQuinidine Action Pathway (New)
smpdb.ca/view/SMP0126282Drug actionSome side effects of using quinidine may include nausea, heartburn, fever, and dizziness. Quinidine is administered as an oral tablet.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferaseTrazodone
go.drugbank.com/drugs/DB00656ApprovedInvestigational[T646] A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy. … [T646] Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters
Synonyms: 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-oneCategories: P-glycoprotein inducers, Cytochrome P-450 SubstratesMupirocin
go.drugbank.com/drugs/DB00410ApprovedInvestigationalVet approvedProduced by fermentation using the organism _Pseudomonas fluorescens_, mupirocin is a naturally-occurring antibiotic that displays a broad-specturm activity against many gram-positive bacteria and certain … Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents.
Synonyms: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3- [(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl] oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid, Pseudomonic acid AInternational brands: T-BactRUS 3108
go.drugbank.com/drugs/DB05911ExperimentalRUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories. … The drug’s Phase I clinical trials have been initiated in Europe to assess safety of the drug compound in healthy volunteers.
Human Umbilical Cord Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15726InvestigationalCurrently many companies are creating their own version of these stem cells, one of which is by Aspire, who are creating a version named ACT-20. … Stem cells from the umbilical cord offer several advantages, including: non-invasive collection procedures, more hearty and steady growth than bone-marrow derived stem cells (they can maintain a steady
Levobunolol
go.drugbank.com/drugs/DB01210ApprovedA nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.
Synonyms: (S)-5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenoneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates