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Solute carrier family 2, facilitated glucose transporter member 4
go.drugbank.com/bio_entities/BE0000893TransporterTargetHumansResponse to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. … Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation.
Synonyms: Glucose transporter type 4, insulin-responsiveCation-independent mannose-6-phosphate receptor
go.drugbank.com/bio_entities/BE0003623TargetTransporterHumansMediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phos...
Synonyms: Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptorHLA class I histocompatibility antigen, A alpha chain
go.drugbank.com/bio_entities/BE0003483TargetHumansTypically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed
Synonyms: Human leukocyte antigen APappalysin-1
go.drugbank.com/bio_entities/BE0009031TargetHumansMetalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence o...
Synonyms: Insulin-like growth factor-dependent IGF-binding protein 4 proteaseCCN family member 3
go.drugbank.com/bio_entities/BE0001147TargetHumansImpairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity).
Synonyms: Insulin-like growth factor-binding protein 9CCN family member 2
go.drugbank.com/bio_entities/BE0013178TargetHumansMajor connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenes...
Synonyms: Insulin-like growth factor-binding protein 8Mitogen-activated protein kinase 3
go.drugbank.com/bio_entities/BE0001062TargetHumansSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participat...
Synonyms: Insulin-stimulated MAP2 kinaseRibosomal protein S6 kinase alpha-3
go.drugbank.com/bio_entities/BE0004876TargetHumansIn response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). … Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835).
Synonyms: Insulin-stimulated protein kinase 1Extracellular signal-regulated kinase (ERK)
go.drugbank.com/bio_entities/BE0009668TargetHumansSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signal...
Synonyms: Insulin-stimulated MAP2 kinaseEph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansIn addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity
Synonyms: Human embryo kinase