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Azathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigational[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection. … Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic
Voriconazole
go.drugbank.com/drugs/DB00582ApprovedInvestigational[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660] … Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.
T-cell surface antigen CD2
go.drugbank.com/bio_entities/BE0000719TargetHumansCD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the si...
Synonyms: LFA-3 receptor, Rosette receptorInositol 1,4,5-trisphosphate-gated calcium channel ITPR3
go.drugbank.com/bio_entities/BE0009595TargetHumansInositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore parti...
Synonyms: IP3 receptor isoform 3, Type 3 InsP3 receptorCilastatin
go.drugbank.com/drugs/DB01597ApprovedInvestigationalThe first combination product containing both drugs was approved by the FDA in November of 1985 under the trade name Primaxin, marketed by Merck & Co. … Since the antibiotic, [imipenem], is one such antibiotic that is hydrolyzed by dehydropeptidase, cilastatin is used in combination with imipenem to prevent its metabolism.
Mixtures: IMIPENEM E CILASTATINA SUN, IMIPENEM E CILASTATINA SUNFenoterol
go.drugbank.com/drugs/DB01288ApprovedWithdrawnFenoterol is an adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
Categories: Agents to Treat Airway Disease, Adrenergic beta-2 Receptor AgonistsInterferon gamma-1b
go.drugbank.com/drugs/DB00033ApprovedInvestigationalProduction of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. … The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Muromonab
go.drugbank.com/drugs/DB00075ApprovedInvestigationalWithdrawnMore specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. … Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens.
Categories: CD3 Receptor AntagonistsAcenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalCoumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation. … [A188739] Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.
Alprenolol
go.drugbank.com/drugs/DB00866ApprovedWithdrawnOne of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. … Alprenolol is no longer marketed by AstraZeneca, but may still be available in generic varieties.
Categories: Serotonin Receptor Antagonists, Serotonin 5-HT1 Receptor Antagonists