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Displaying results 311 - 320 of 10000 in total
  1. Drug

    Potassium bicarbonate

    go.drugbank.com/drugs/DB11098
    ApprovedInvestigational

    Potassium bicarbonate is a white, crystalline, slightly alkaline and salty substance. It is produced by the passage of carbon dioxide through an aqueous potassium carbonate solution. … It is used in medicine as an antacid.[T141] It is registered in the FDA under the section of suitable, safe and effective ingredients for OTC antacids.

    Mixtures: Neo K, Buffered Vitamin C Pwr W Cal-mag-potassiumProducts: Klor-con/ef, KLOR-Con/EF
  2. Drug

    Phenytoin

    go.drugbank.com/drugs/DB00252
    ApprovedInvestigationalVet approved

    [A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications … [A188826,A188832] Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal

    Mixtures: Dilantin W Phenobarbital 30mg Cap, Dilantin W Phenobarbital 15mgCategories: Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic Index
  3. Drug

    Captopril

    go.drugbank.com/drugs/DB01197
    ApprovedInvestigational

    Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.

    Synonyms: D-2-methyl-3-mercaptopropanoyl-L-proline, D-3-mercapto-2-methylpropanoyl-L-prolineMixtures: CO-ALTIVER, CAPTOPRIL E IDROCLOROTIAZIDE HEXAL
  4. Target

    cAMP-dependent protein kinase type I-alpha regulatory subunit

    go.drugbank.com/bio_entities/BE0003425
    TargetHumans

    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

    Polypeptides: cAMP-dependent protein kinase type I-alpha regulatory subunit
  5. Drug

    Homosalate

    go.drugbank.com/drugs/DB11064
    Approved

    Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. … It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate.

    Synonyms: 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoateMixtures: Skin Care Prescription, GoodSense SPF 50 Sport Comfort Can
  6. Drug

    Daclatasvir

    go.drugbank.com/drugs/DB09102
    ApprovedInvestigationalWithdrawn

    Hepatitis C is an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … It exerts its antiviral action by preventing RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: I-HEP CLASTAVIR 30, I-HEP CLASTAVIR 60
  7. Target

    Nuclear receptor subfamily 1 group I member 2

    go.drugbank.com/bio_entities/BE0000956
    TargetHumans

    Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progest...

    Polypeptides: Nuclear receptor subfamily 1 group I member 2
  8. Target

    Nuclear receptor subfamily 1 group I member 3

    go.drugbank.com/bio_entities/BE0003848
    TargetHumans

    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP...

    Polypeptides: Nuclear receptor subfamily 1 group I member 3Synonyms: CAR
  9. Target

    High mobility group protein HMG-I/HMG-Y

    go.drugbank.com/bio_entities/BE0012648
    TargetHumans

    HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA.

    Polypeptides: High mobility group protein HMG-I/HMG-YSynonyms: HMG-I(Y)
  10. Drug

    Formoterol

    go.drugbank.com/drugs/DB00983
    ApprovedInvestigational

    [L10986] It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. … Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001.

    Mixtures: FORMODUAL N. 200/6UG, FORMODUAL N. 200/6UGCategories: Agents to Treat Airway Disease, Cytochrome P-450 Substrates