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Displaying results 3271 - 3280 of 10000 in total
  1. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

    go.drugbank.com/bio_entities/BE0000525
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respi...

    Synonyms: Gene associated with retinoic and IFN-induced mortality 19 protein, Gene associated with retinoic and interferon-induced mortality 19 protein
  2. Drug

    Zileuton

    go.drugbank.com/drugs/DB00744
    ApprovedWithdrawn

    Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market. … Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.

    Synonyms: (±)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
  3. Drug

    Acoramidis

    go.drugbank.com/drugs/DB17999
    ApprovedInvestigational

    [A264768] Acoramidis has been in development since at least 2013. … [A264768] Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis.

    Synonyms: 3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acidCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 Inhibitors
  4. Drug

    Amylmetacresol

    go.drugbank.com/drugs/DB13908
    Approved

    The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. … Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections [L2570], [L2571].

    Synonyms: 6-n-amyl-m-cresol, 6-n-pentyl-m-cresolMixtures: ซีพาคอล(R) อาร์เอ็กซ์, ซีพาคอล(R) อาร์เอ็กซ์
  5. Drug

    Pork collagen

    go.drugbank.com/drugs/DB14100
    Approved

    It has been used since 1995 as Carticel and gained biologic license in 1997. The surgical implantation was first performed in Sweden. … The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not indicated for patients with osteoarthritis.

  6. Drug

    Tandutinib

    go.drugbank.com/drugs/DB05465
    Investigational

    Approximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. … MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  7. Drug

    Zucapsaicin

    go.drugbank.com/drugs/DB09120
    ApprovedWithdrawn

    It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid or capsaicin receptor 1, that reduces pain and improves articular functions. … Zucapsaicin has also been evaluated for the management of several conditions manifested by chronic nerve pain.

    Synonyms: (Z)-CapsaicinCategories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C19 Inhibitors
  8. Target

    Guanylyl cyclase C

    go.drugbank.com/bio_entities/BE0003502
    TargetHumans

    Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1680854, PubMed:1718270).

    Synonyms: STA receptor, Heat-stable enterotoxin receptor
  9. Target

    Prohibitin-2

    go.drugbank.com/bio_entities/BE0009007
    TargetHumans

    Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcrip...

    Synonyms: B-cell receptor-associated protein BAP37, Repressor of estrogen receptor activity
  10. Drug

    Anisotropine methylbromide

    go.drugbank.com/drugs/DB00517
    Approved

    Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. … Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant

    Synonyms: 8-Methyl-3-(2-propylpentanoyloxy)tropinium bromide, endo-8,8-Dimethyl-3-((1-oxo-2-propylpentyl)oxy)-8-azoniabicyclo(3.2.1)octane bromide