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Darvadstrocel
go.drugbank.com/drugs/DB16581ApprovedInvestigationalWithdrawnPerianal fistula is a common manifestation of Crohn’s disease and is often difficult to manage, as it may be associated with complex presentations and symptoms. … It is indicated for the treatment of complex perianal fistulas in adult patients with non-active or mildly active luminal Crohn’s disease when fistulas have shown an inadequate response to at least one
Ibalizumab
go.drugbank.com/drugs/DB12698ApprovedInvestigationalIbalizumab (also known as ibalizumab-uiyk and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and...
Amphetamine
go.drugbank.com/drugs/DB00182ApprovedIllicitInvestigationalAmphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Ampheta...
Zolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigationalZolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)1B/1D/(1F) receptor agonists used to treat acute migraine. Sumatriptan was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. ...
Vinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalVinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC) . It was initially approved in the USA in 1990's for the trea...
Sulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigational[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down into [mesalazine] and [sulfapyridine], 2 compounds that carry out the main pharmacological activity of sulfasalazine. … However, sulfasalazine has less teratogenic side effects and faster onset of action compared to conventional DMARD.
Glasdegib
go.drugbank.com/drugs/DB11978ApprovedInvestigational[A258493] Aberrant of Hh signaling is one of the main pathophysiologies of AML, with observed overexpression or constitutive activation of SMO.
19-norandrostenedione
go.drugbank.com/drugs/DB01434ExperimentalIllicit19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substa...
MPI-674
go.drugbank.com/drugs/DB05749ExperimentalAIs are a class of drugs that reduce the amount of estrogen circulating in the body by binding to and inhibiting the enzyme aromatase, which is responsible for converting certain hormones to estrogen.
Tyramine
go.drugbank.com/drugs/DB08841InvestigationalNutraceuticalThere have been reports of hypertensive crisis in patients ingesting tyramine-rich diet in conjunction with monoamine oxidase inhibitors (MAOIs).