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Displaying results 3291 - 3300 of 10000 in total
  1. Target

    Galectin-10

    go.drugbank.com/bio_entities/BE0001886
    TargetHumans

    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg)

    Polypeptides: Galectin-10Synonyms: Gal-10
  2. Target

    Frizzled-10

    go.drugbank.com/bio_entities/BE0020969
    TargetHumans

    Both pathways seem to involve interactions with G proteins. … pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.

    Polypeptides: Frizzled-10Synonyms: Fz-10
  3. Drug

    REN-850

    go.drugbank.com/drugs/DB05912
    Experimental

    REN-850 is an oral drug for multiple sclerosis which is in Phase I of clinical trials.

  4. Drug

    Abrilumab

    go.drugbank.com/drugs/DB15076
    Investigational

    Abrilumab is under investigation in clinical trial NCT01290042 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.).

  5. Drug

    Maftivimab

    go.drugbank.com/drugs/DB15899
    ApprovedInvestigational

    [A221825] Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid development, low toxicity, and high … INMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020.[L17320]

  6. Target

    Interleukin-10

    go.drugbank.com/bio_entities/BE0002484
    TargetHumans

    Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). … In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162).

    Polypeptides: Interleukin-10Synonyms: IL-10
  7. Target

    Aquaporin-10

    go.drugbank.com/bio_entities/BE0018706
    TransporterHumans

    Could also be permeable to urea (PubMed:12084581). Among aquaglyceroporins, it exhibits a unique pH-gated glycerol transport activity, being more active at acidic pH.

    Polypeptides: Aquaporin-10Synonyms: AQP-10, Aquaglyceroporin-10
  8. Drug

    Tegafur-uracil

    go.drugbank.com/drugs/DB09327
    Approved

    It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd.[A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA. … Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  9. Drug

    Polysilicone-15

    go.drugbank.com/drugs/DB11271
    Approved

    It is the first polymeric UVB filer consisting of chromophores attached to a silicone backbone [L2796, L2797, L2799, F87, F88, F89]. … The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89].

  10. Indication

    Helminth Infection

    go.drugbank.com/conditions/DBCOND0082009
    Drugs: Flubendazole · Niclosamide · Oxantel · Pyrantel
    Synonyms: Infection due to Class Cestoda and/or Class Trematoda and/or Phylum Nemata