Search

Displaying results 3331 - 3340 of 10000 in total
  1. Target

    Camphor 5-monooxygenase

    go.drugbank.com/bio_entities/BE0001246
    TargetPseudomonas putida

    Involved in a camphor oxidation system.

    Polypeptides: Camphor 5-monooxygenaseFunction: camphor 5-monooxygenase activity
  2. Drug

    Pentosan polysulfate

    go.drugbank.com/drugs/DB00686
    ApprovedInvestigational

    Pentosan polysulfate is a sulfated pentosyl polysaccharide with heparin-like properties.

    Synonyms: (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULFATE, (4-O-METHYL-.ALPHA.-D-GLUCURONO)-(1->2)-(1->4)-.BETA.-D-XYLOPYRANAN, HYDROGEN SULPHATEProducts: ELMIRON 100 MG KAPSÜL, 100 ADET, Elmidam 100 mg Sert Kapsül, 100 ADET
  3. Drug

    Pitavastatin

    go.drugbank.com/drugs/DB08860
    ApprovedInvestigational

    [A181087, A181406] Evidence has shown that even for low-risk individuals (with <10% risk of a major vascular event occurring within 5 years) statins cause a 20%-22% relative reduction in major cardiovascular … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Trolise 1 mg Filmtabletten, PITAMIN 1 MG EFERVESAN TABLET, 30 ADET
  4. Drug

    Idarucizumab

    go.drugbank.com/drugs/DB09264
    Approved

    , concomitant NSAID or warfarin use, etc). … Idarucizumab protein structure can be viewed below, with disulfide bridges at the following points: H22-H95, H149-H205, H225-L-219, L23-L93, L139-L199.

    Products: PRAXBIND Solution for Injection/Infusion 50 mg/ml, PRAXBİND 50 MG/ML ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ, 2 ADET
  5. Drug

    Safinamide

    go.drugbank.com/drugs/DB06654
    ApprovedInvestigational

    It was approved in Europe in February 2015, and in the United States on March 21, 2017.

    Categories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesProducts: Equfina Film coated Tablets 50 mg, XADAGO 50 MG TABLETAS RECUBIERTAS CON PELÍCULA
  6. Drug

    Simeprevir

    go.drugbank.com/drugs/DB06290
    ApprovedWithdrawn

    Broad use of simeprevir occurred when it was used in combination with a newer drug, [DB08934]. … or PEG-Interferon/ribavirin combination therapy for genotype 1 or 4.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: OLYSIO 150 MG KAPSUL ,KAPSUL, 28 ADET
  7. Drug

    Sotorasib

    go.drugbank.com/drugs/DB15569
    ApprovedInvestigational

    Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen. … [A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS mutations.

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsSynonyms: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one, Kras G12C inhibitor 9
  8. Drug

    Ranolazine

    go.drugbank.com/drugs/DB00243
    ApprovedInvestigational

    [L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] … Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.

    Categories: MATE 1 Inhibitors, Heterocyclic Compounds, 1-RingProducts: RANOLAZINA EG, RAZİNA 1000 MG UZATILMIŞ SALIMLI TABLET, 60 ADET
  9. Drug

    Perazine

    go.drugbank.com/drugs/DB12710
    ApprovedWithdrawn

    Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

    Categories: Heterocyclic Compounds, 3-RingProducts: PERAZIN-NEURAX 100 MG, PERAZIN-NEURAX 25 MG
  10. Pathway

    Acylcarnitine 10-Hydroxydodec-5-enedioylcarnitine

    smpdb.ca/view/SMP0124031
    Metabolic

    10-Hydroxydodec-5-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 10-hydroxydodec-5-enedioyl-CoA reacts with L-carnitine to form 10-hydroxydodec-5-enedioylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5