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Displaying results 3371 - 3380 of 10000 in total
  1. Drug

    Regorafenib

    go.drugbank.com/drugs/DB08896
    ApprovedInvestigational

    FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in April 2017.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsProducts: STIVARGA 40 MG TABLETA RECUBIERTA, STIVARGA 40 MG FILM KAPLI TABLET ,84 ADET
  2. Drug

    Benmelstobart

    go.drugbank.com/drugs/DB17473
    Investigational

    APL 502 is a humanised immunoglobulin G1 (IgG1) monoclonal antibody targeting the programmed cell death-1 ligand-1 (PD-L1).

    Synonyms: , G1v66 CH2 A27 (CH1 K120(213) (117-214), hinge 1-15, gamma1 heavy chain humanized (1-446) [VH (Homo sapiens IGHV2-5*01 (78.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14
  3. Drug

    Phenprocoumon

    go.drugbank.com/drugs/DB00946
    ApprovedInvestigationalWithdrawn

    Coumarin derivative that acts as a long-acting oral anticoagulant.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesSynonyms: 3-(1-Phenylpropyl)-4-hydroxycoumarin, 3-(1'-Phenyl-propyl)-4-oxycoumarin
  4. Drug

    Tolfenamic acid

    go.drugbank.com/drugs/DB09216
    Approved

    Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. … It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: TOLFEDINE TABLETS 6 MG, TOLFEDINE TABLET 60 MG
  5. Drug

    Hepatitis A Vaccine

    go.drugbank.com/drugs/DB10989
    ApprovedInvestigational

    [A199182] Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infection and safely confers strong protection … Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure.

    Synonyms: Hepatitis A Vaccine, Hepatitis A vaccine, inactivatedSalts: Hepatitis A virus strain CR 326F antigen (formaldehyde inactivated), Hepatitis A virus strain HM175 antigen (formaldehyde inactivated)
  6. Drug

    Belatacept

    go.drugbank.com/drugs/DB06681
    ApprovedInvestigational

    FDA approved on June 15, 2011. … Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it is a homodimer of two homologous polypeptide chains of 357 amino acids each.

    Categories: Selective T Cell Costimulation Blocker, T Lymphocyte Costimulation Activity BlockadeProducts: NULOJIX ®250 MG/ VIAL POLVO LIOFILIZADO PARA SOLUCION INYECTABLE INTRAVENOSA
  7. Drug

    Sulfamethizole

    go.drugbank.com/drugs/DB00576
    ApprovedVet approved

    A sulfathiazole antibacterial agent.

    Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: S- URISTIX 500 MG CAPSULAS, S*ORIPOL FORTE - SULFAMETIZOL 500 MG CAPSULAS
  8. Drug

    Pivampicillin

    go.drugbank.com/drugs/DB01604
    ApprovedWithdrawn

    Pivalate ester analog of ampicillin.

    Categories: Penicillin G, Heterocyclic Compounds, 2-RingProducts: PIVACIL KAPSUL 350 MG, 1000 ADET, PIVACIL KAPSUL 350 MG, 500 ADET
  9. Drug

    Niclosamide

    go.drugbank.com/drugs/DB06803
    ApprovedInvestigationalVet approved

    Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. … Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsProducts: YOMESAN 500 MG TABLET, 4 ADET, YOMESAN 500 MG TABLET, 500 ADET
  10. Target

    Retinol dehydrogenase 5

    go.drugbank.com/bio_entities/BE0000570
    TargetEnzymeHumans

    Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293). Has no activity towards all-trans retinal (By...

    Polypeptides: Retinol dehydrogenase 5Synonyms: Short chain dehydrogenase/reductase family 9C member 5