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Displaying results 3441 - 3450 of 10000 in total
  1. Target

    Peroxiredoxin-5, mitochondrial

    go.drugbank.com/bio_entities/BE0000907
    TargetEnzymeHumans

    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor o...

    Polypeptides: Peroxiredoxin-5, mitochondrialSynonyms: Thioredoxin-dependent peroxiredoxin 5
  2. Target

    5-aminolevulinate synthase

    go.drugbank.com/bio_entities/BE0002158
    TargetHumans

    Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.

    Polypeptides: 5-aminolevulinate synthaseSynonyms: 5-aminolevulinic acid synthase
  3. Target

    Integrin alpha-5

    go.drugbank.com/bio_entities/BE0008988
    TargetHumans

    Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands.

    Polypeptides: Integrin alpha-5Synonyms: VLA-5
  4. Target

    Thyroxine 5-deiodinase

    go.drugbank.com/bio_entities/BE0009333
    TargetEnzymeHumans

    T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722, PubMed:18339710 … Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-

    Polypeptides: Thyroxine 5-deiodinaseFunction: thyroxine 5'-deiodinase activity
  5. Target

    Pseudouridine-5'-phosphatase

    go.drugbank.com/bio_entities/BE0014361
    EnzymeHumans

    Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine

    Polypeptides: Pseudouridine-5'-phosphataseSynonyms: 5'-PsiMPase, Pseudouridine-5'-monophosphatase
  6. Target

    NADPH oxidase 5

    go.drugbank.com/bio_entities/BE0018640
    TargetHumans

    Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:12686516). Also synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling...

    Polypeptides: NADPH oxidase 5
  7. Target

    Camphor 5-monooxygenase

    go.drugbank.com/bio_entities/BE0001246
    TargetPseudomonas putida

    Involved in a camphor oxidation system.

    Polypeptides: Camphor 5-monooxygenaseFunction: camphor 5-monooxygenase activity
  8. Drug

    Molsidomine

    go.drugbank.com/drugs/DB09282
    ApprovedWithdrawn

    Interestingly, it is being studied as being a preventive measure in cerebral infarction [A31932].

    Categories: Heterocyclic Compounds, 1-RingProducts: Molsidolat 4 mg Tabletten, Nesidom 16 mg - Retardtabletten
  9. Drug

    Deucravacitinib

    go.drugbank.com/drugs/DB16650
    ApprovedInvestigational

    Unlike other Janus kinase 1/2/3 inhibitors that bind to the conserved active domain of these non-receptor tyrosine kinases, deucravacitinib binds to the regulatory domain of TYK2 with high selectivity … Deucravacitinib is a novel oral selective tyrosine kinase 2 (TYK2) inhibitor.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: SOTYKTU 6 mg film coated tablets, SOTYKTU® 6MG TABLETAS RECUBIERTAS
  10. Drug

    Squalene

    go.drugbank.com/drugs/DB11460
    ApprovedInvestigationalVet approvedWithdrawn

    It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection.

    Synonyms: (E,E,E,E)-Squalene, (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaeneMixtures: K-OMEGASQUA (Softgel)