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Displaying results 3531 - 3540 of 10000 in total
  1. Drug

    H3B-8800

    go.drugbank.com/drugs/DB14017
    Investigational

    H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine [L2551].

    Synonyms: 1-PIPERAZINECARBOXYLIC ACID, 4-METHYL-, (2S,3S,4E,6S,7R,10R)-7,10-DIHYDROXY-3,7-DIMETHYL-2-((1E,3E,5R)-1-METHYL-5-(2-PYRIDINYL)-1,3-HEXADIEN-1-YL)-12-OXOOXACYCLODODEC-4-EN-6-YL ESTER, (2S,3S,4E,6S,7R,10R)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-(2-pyridinyl)-2,4-heptadien-2-yl]oxacyclododec-4-en-6-yl 4-methyl-1-piperazinecarboxylateCategories: Heterocyclic Compounds, 1-Ring
  2. Drug

    Abiprubart

    go.drugbank.com/drugs/DB19333
    Investigational

    Abiprubart is being evaluated for its efficacy and safety in participants with Sjögren's Disease in clinical trial NCT06531395

    Synonyms: Immunoglobulin G4-kappa, anti-[Homo sapiens CD40 (TNFRSF5, tumor necrosis factor receptor (TNFR) superfamily member 5, p50)], humanized monoclonal antibody, Gamma4 heavy chain humanized (1-441) [VH (Homo sapiens IGHV1-3*01 (83.7%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.7] (26-33.51-58.97-103)) (1-114)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1
  3. Indication

    Invasive Infection caused by Streptococcus pneumoniae serotype 5

    go.drugbank.com/conditions/DBCOND0093623
    Drugs: Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria CRM197 protein conjugate antigen
    Synonyms: Invasive Infection caused by Streptococcus pneumoniae serotype 5
  4. Drug

    Dapoxetine

    go.drugbank.com/drugs/DB04884
    Investigational

    In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. … Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.

    Mixtures: DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET, DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inhibitors
  5. Drug

    Probenecid

    go.drugbank.com/drugs/DB01032
    ApprovedInvestigational

    The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubu...

    Synonyms: 4-(N,N-Dipropylsulfamoyl)benzoesäure, 4-(Di-n-propylsulfamoyl)benzoesäureCategories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 CYP3A Inducers
  6. Target

    Tryptophan 5-hydroxylase 1

    go.drugbank.com/bio_entities/BE0000121
    TargetEnzymeHumans

    Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis

    Polypeptides: Tryptophan 5-hydroxylase 1Synonyms: Tryptophan 5-monooxygenase 1
  7. Target

    Cytosolic purine 5'-nucleotidase

    go.drugbank.com/bio_entities/BE0000261
    TargetEnzymeHumans

    Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705).

    Polypeptides: Cytosolic purine 5'-nucleotidaseSynonyms: High Km 5'-nucleotidase, Cytosolic 5'-nucleotidase II
  8. Target

    5'(3')-deoxyribonucleotidase, mitochondrial

    go.drugbank.com/bio_entities/BE0001515
    TargetHumans

    Dephosphorylates preferentially the 5'- and 2'(3')-phosphates of uracil and thymine (deoxy)ribonucleotide monophosphates (PubMed:10899995, PubMed:16004879).

    Polypeptides: 5'(3')-deoxyribonucleotidase, mitochondrialSynonyms: Deoxy-5'-nucleotidase 2, 5',3'-nucleotidase, mitochondrial
  9. Target

    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

    go.drugbank.com/bio_entities/BE0001620
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

    Polypeptides: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferaseFunction: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
  10. Target

    Orotidine 5'-phosphate decarboxylase

    go.drugbank.com/bio_entities/BE0001677
    TargetEnzymeEscherichia coli (strain K12)

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

    Polypeptides: Orotidine 5'-phosphate decarboxylase