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Displaying results 3581 - 3590 of 10000 in total
  1. Target

    Retinol dehydrogenase 12

    go.drugbank.com/bio_entities/BE0000726
    TargetHumans

    May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838). … Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:12226107, PubMed:15865448).

    Synonyms: All-trans and 9-cis retinol dehydrogenase
  2. Target

    Myeloid zinc finger 1

    go.drugbank.com/bio_entities/BE0013131
    TargetHumans

    Binds to target promoter DNA and functions as a transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter.

    Synonyms: Zinc finger and SCAN domain-containing protein 6
  3. Indication

    Dementia, Multi-Infarct

    go.drugbank.com/conditions/DBCOND0006170
    Drugs: Choline alfoscerate
    Synonyms: Vascular dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety
  4. Indication

    Headache, Cluster

    go.drugbank.com/conditions/DBCOND0172067
    Drugs: Dihydroergotamine · Ergotamine · Mecloxamine · Verapamil · Zolmitriptan
    Synonyms: Cluster headaches and other trigeminal autonomic cephalgias (TAC)
  5. Indication

    Lymphogranuloma Venereum

    go.drugbank.com/conditions/DBCOND0005917
    Drugs: Doxycycline · Erythromycin · Minocycline · Tetracycline
    Synonyms: Climatic AND/OR tropical bubo
  6. Indication

    Non-q wave myocardial infarction

    go.drugbank.com/conditions/DBCOND0023450
    Drugs: Nadroparin
    Synonyms: Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction
  7. Drug

    Benzthiazide

    go.drugbank.com/drugs/DB00562
    Approved

    They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. … Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

    Categories: Genito Urinary System and Sex Hormones, Gynecological Antiinfectives and Antiseptics
  8. Drug

    Diphenylguanidine

    go.drugbank.com/drugs/DB14191
    Approved

    Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. … It is also a dermatological sensitizer and allergen. Sensitivity to diphenylguanidine may be identified with a clinical patch test.

    Synonyms: N,N'-diphenylguanidine
  9. Drug

    Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells

    go.drugbank.com/drugs/DB15731
    Investigational

    The isolated cells are expanded in culture and are able to be used allogenically -- meaning that one donor’s cells can be given to other unrelated patients. … Regarding the modifications of these UC-MSCs, CD362, also known as syndecan-2, is a surface marker identified on MSCs with enhanced clonogenicity and immunomodulatory properties.

  10. Drug

    Modafinil

    go.drugbank.com/drugs/DB00745
    ApprovedInvestigational

    The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular … Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil.

    Categories: Modafinil and isomer, Metabolic Side Effects of Drugs and SubstancesProducts: CARIM 200MG