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3',5'-cyclic-AMP phosphodiesterase 4D
go.drugbank.com/bio_entities/BE0001287TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4DFunction: 3',5'-cyclic-AMP phosphodiesterase activitycGMP-dependent 3',5'-cyclic phosphodiesterase
go.drugbank.com/bio_entities/BE0002085TargetHumanscGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Ha...
Polypeptides: cGMP-dependent 3',5'-cyclic phosphodiesteraseFunction: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activitytRNA (cytosine(38)-C(5))-methyltransferase
go.drugbank.com/bio_entities/BE0002517TargetHumansSpecifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495)
Polypeptides: tRNA (cytosine(38)-C(5))-methyltransferaseSynonyms: DNA (cytosine-5)-methyltransferase-like protein 2Trafficking protein particle complex subunit 5
go.drugbank.com/bio_entities/BE0004277TargetHumansMay play a role in vesicular transport from endoplasmic reticulum to Golgi
Polypeptides: Trafficking protein particle complex subunit 5Pregnancy-specific beta-1-glycoprotein 5
go.drugbank.com/bio_entities/BE0008996TargetHumansPolypeptides: Pregnancy-specific beta-1-glycoprotein 5Synonyms: PSBG-5, PS-beta-G-5Pyridoxal 5'-phosphate synthase subunit Pdx1
go.drugbank.com/bio_entities/BE0009271TargetPlasmodium falciparum (isolate 3D7)Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. … Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Polypeptides: Pyridoxal 5'-phosphate synthase subunit Pdx1G protein-coupled receptor kinase 5
go.drugbank.com/bio_entities/BE0013072TargetHumansSerine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization,...
Polypeptides: G protein-coupled receptor kinase 5Short transient receptor potential channel 5
go.drugbank.com/bio_entities/BE0021113TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with...
Polypeptides: Short transient receptor potential channel 5Synonyms: hTRP-5, TRP-5Asciminib
go.drugbank.com/drugs/DB12597ApprovedInvestigational[L38995,A241055] Asciminib received FDA approval on October 29, 2021 (Scemblix, Novartis AG).[L39000] … More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995] which serves as a driver of CML proliferation in most patients with the disease.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: AZEVAY 20 MG FİLM KAPLI TABLET , 60 ADET, AZEVAY 40 MG FİLM KAPLI TABLET , 60 ADETRimonabant
go.drugbank.com/drugs/DB06155ApprovedWithdrawnThis decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression. … It was rejected for approval for use in the United States.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: ACOMPLIA ® COMPRIMIDOS RECUBIERTOS20 MG