Search
Valbenazine
go.drugbank.com/drugs/DB11915ApprovedInvestigationalThe reduction in chorea severity was observed as early as 2 weeks after starting treatment with an initial dose of 40 mg.[L47910] … [A261165] However, challenges in using [tetrabenazine] as a treatment of tardive dyskinesia included frequent dosing and safety and tolerability concerns.
Categories: Amino Acids, Peptides, and Proteins, Cytochrome P-450 SubstratesProducts: REMLEAS HARD CAPSULES 40 MG, REMLEAS™ hard capsules 40mgRamosetron
go.drugbank.com/drugs/DB09290InvestigationalRamosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. … It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: IRRIBOW TABLET 5 MCG, NASEA(R) TABLET 0.1 MGValerian
go.drugbank.com/drugs/DB13196ApprovedValerian is extracted from a herb that is a perennial flowering plant. Valerian root is reported to have sedative and anxiolytic effects however its mechanism of action is not completely understood. … Valerian has been used in the treatment of conditions including sleep disorders, anxiety, attention deficit-hyperactivity disorder (ADHD) and joint pain.
Mixtures: Valerian and Hops Tablets, Sanhelios Valerian Pearls and HopsCategories: Hypnotics and Sedatives, Herbs and Natural ProductsNicotinamide
go.drugbank.com/drugs/DB02701ApprovedInvestigationalAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. … Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Mixtures: Multivitamin with 1.0 mg Fluoride, B Plus C 300 mgCategories: Heterocyclic Compounds, 1-Ring, Alimentary Tract and MetabolismPrednicarbate
go.drugbank.com/drugs/DB01130ApprovedIL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness. … The anti-inflammation action of corticosteroids is associated with the inhibition of the interleukin 1-alpha cytokine within keratinocytes.
Mixtures: SKINPRED® ULTRACategories: Hormones, Hormone Substitutes, and Hormone Antagonists, Cytochrome P-450 SubstratesMetyrapone
go.drugbank.com/drugs/DB01011ApprovedInvestigationalAn inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2A6 InhibitorsProducts: Metycor 250 mg WeichkapselnSolute carrier family 12 member 5
go.drugbank.com/bio_entities/BE0000047TargetTransporterHumansMediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required...
Polypeptides: Solute carrier family 12 member 5cGMP-specific 3',5'-cyclic phosphodiesterase
go.drugbank.com/bio_entities/BE0000182TargetEnzymeHumansThis phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334)
Polypeptides: cGMP-specific 3',5'-cyclic phosphodiesteraseFunction: 3',5'-cyclic-AMP phosphodiesterase activity3',5'-cyclic-AMP phosphodiesterase 4B
go.drugbank.com/bio_entities/BE0000487TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to...
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4BFunction: 3',5'-cyclic-AMP phosphodiesterase activityDelta-1-pyrroline-5-carboxylate synthase
go.drugbank.com/bio_entities/BE0000823TargetHumansBifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine
Polypeptides: Delta-1-pyrroline-5-carboxylate synthase