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Gliquidone
go.drugbank.com/drugs/DB01251ApprovedGliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. … This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.
Categories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesProducts: GLURENOR 30 MG TABLETTEN, Glurenorm 30 mg - TablettenMefloquine
go.drugbank.com/drugs/DB00358ApprovedIndividuals at the highest risk for malaria are those in disease naïve populations, children under age 5, refugees in Central and Eastern Africa, nonimmune civilian and military travelers, pregnant women … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world.
Mixtures: อาร์ทีซูเนทและเมฟลอควินไฮโดรคลอไรด์ 25/55 มก.Categories: P-glycoprotein inhibitors, P-glycoprotein substratesLuspatercept
go.drugbank.com/drugs/DB12281ApprovedInvestigational[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients with beta thalassemia who require regular blood … Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.
Products: Reblozyl 25 mg powder for solution for injection, Reblozyl 75 mg powder for solution for injectionApis mellifera venom
go.drugbank.com/drugs/DB10955ApprovedApis mellifera venom is an extract of Apis mellifera venom. Apis mellifera venom is used in allergenic testing.
Mixtures: ALUTARD SQ Bienengift Injektionssuspension (Anfangsbehandlung) (100 SQ E/ml, 1.000 SQ E/ml, 10.000 SQ E/ml und 100.000 SQ E/ml), ALUTARD SQ Bienengift Injektionssuspension (Anfangsbehandlung) (100 SQ E/ml, 1.000 SQ E/ml, 10.000 SQ E/ml und 100.000 SQ E/ml)Products: ALUTARD SQ Bienengift 100.000 SQ-E/ml Injektionssuspension (Fortsetzungsbehandlung), Venomil Inj 10mcg/ml Honey BeeNiclosamide
go.drugbank.com/drugs/DB06803ApprovedInvestigationalVet approvedOver 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. … Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases.
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesProducts: YOMESAN 500 MG TABLET, 4 ADET, YOMESAN 500 MG TABLET, 500 ADETVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … The Hedgehog signaling pathway plays an important role in the development of organs and tissues during embryogenesis.
Synonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTrastuzumab emtansine
go.drugbank.com/drugs/DB05773ApprovedInvestigationalTrastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent … Trastuzumab emtansine is marketed under the brand name Kadcyla and is indicated for use in HER2-positive, metastatic breast cancer patients who have already used taxane and/or trastuzumab for metastatic
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: T-DM1Manganese cation
go.drugbank.com/drugs/DB06757ApprovedInvestigationalNutraceuticalManganese is a transition metal that was first described in the 19th and 20th centuries. … [A263687, A263662] In humans, manganese regulates several physiological processes by acting as a cofactor for proteins [A263657, A263662, A263667] making it an essential metal for normal development and
Mixtures: Calcium With Mg Zn Mn Cu CR Si and Vit. C & D, M T E 4 Concentrate InjSynonyms: MANGANESE(2+), MANGANESE ION(2+)Acylcarnitine 2-hydroxyhept-5-enoylcarnitine
smpdb.ca/view/SMP0123357Metabolic2-hydroxyhept-5-enoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 2-hydroxyhept-5-enoyl-CoA reacts with L-carnitine to form 2-hydroxyhept-5-enoylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Solute carrier family 22 member 5Acylcarnitine 5-hydroxyoct-2-enedioylcarnitine
smpdb.ca/view/SMP0123386Metabolic5-hydroxyoct-2-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 5-hydroxyoct-2-enedioyl-CoA reacts with L-carnitine to form 5-hydroxyoct-2-enedioylcarnitine. This reaction is catalyzed by carnitine O-palmitoyltransferase.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreEnzymes: Solute carrier family 22 member 5