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Displaying results 3901 - 3910 of 10000 in total
  1. Drug

    Bretylium

    go.drugbank.com/drugs/DB01158
    Approved

    Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site. … The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels.

    Synonyms: 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium, N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminiumMixtures: Bretylium Tosylate 0.4% and Dextrose 5% Inj, Bretylium Tosylate 0.2% and Dextrose 5% Inj
  2. Drug

    Dihydroxyaluminum sodium carbonate

    go.drugbank.com/drugs/DB15825
    Investigational

    Products: KOMPENSAN 340 MG TABLET, 24 ADET, KOMPENSAN 340 MG TABLET, 40 ADET
  3. Drug

    Sodium molybdate

    go.drugbank.com/drugs/DB14496
    Approved

    Mixtures: TRACUTIL® 10 ML AMPOLLAS, Multi Cal Mag LiquidProducts: GENERADOR MON TEK99 MO /TC 99 M
  4. Target

    Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

    go.drugbank.com/bio_entities/BE0003323
    TargetHumans

    Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference f...

    Polypeptides: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  5. Target

    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

    go.drugbank.com/bio_entities/BE0003557
    TargetHumans

    Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity).

    Polypeptides: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaFunction: 3',5'-cyclic-GMP phosphodiesterase activity
  6. Drug

    Dimethyl sulfoxide

    go.drugbank.com/drugs/DB01093
    ApprovedInvestigationalVet approved

    A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. … Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

    Synonyms: S(O)Me2Categories: Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP2D6 Inhibitors
  7. Drug

    Tianeptine

    go.drugbank.com/drugs/DB09289
    Investigational

    Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) [A31983]. … Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses different pharmacological properties than typical tricyclic antidepressants [A31969].

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: STABLON TABLET 12.5 mg, STABLON 12.5 MG TABLET, 60 ADET
  8. Indication

    Orotic aciduria

    go.drugbank.com/conditions/DBCOND0024003
    Drugs: Uridine triacetate
    Synonyms: Deficiency of orotidine-5'-phosphate pyrophosphorylase
  9. Drug

    Peanut

    go.drugbank.com/drugs/DB10553
    Approved

    Peanut allergenic extract is used in allergenic testing.

    Mixtures: PALFORZIA (Level 7), PALFORZIA (Level 7)Products: PALFORZIA (Level 5), PALFORZIA (Level 1)
  10. Drug

    Fexinidazole

    go.drugbank.com/drugs/DB12265
    Approved

    [A237550, A237560] Fexinidazole, which was originally developed in the 1970s/80s by Hoechst AG and subsequently rediscovered through the Drugs for Neglected Diseases Initiative (DNDi) in 2005, is the first … Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Substrates