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Displaying results 3911 - 3920 of 9322 in total
  1. Drug

    Sulfametopyrazine

    go.drugbank.com/drugs/DB00664
    ApprovedWithdrawn

    Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.

  2. Drug

    Tandutinib

    go.drugbank.com/drugs/DB05465
    Investigational

    Approximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. … Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth.

  3. Drug

    AdPEDF

    go.drugbank.com/drugs/DB05138
    Experimental

    It has been shown to rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal blood vessel growth, and cause abnormal blood vessels to regress while protecting the eye’s photoreceptors … AdPEDF is under development for the treatment of wet age-related macular degeneration (AMD).

  4. Drug

    TGAAC94

    go.drugbank.com/drugs/DB06175
    Investigational

    The Health Recombinant DNA Advisory Committee (RAC) concluded that a possible role of the gene transfer in this clinical course could not definitively be excluded due to the lack of data. [A264038] … It was under investigation in clinical trials to treat Inflammatory Arthritis. In 2007, one patient participating in the clinical trial died and the trial was placed on clinical hold by the FDA.

  5. Drug

    7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

    go.drugbank.com/drugs/DB08550
    Experimental

    Potent reversible inhibitor of phenylethanolamine N-methyltransferase.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  6. Drug

    Tenocyclidine

    go.drugbank.com/drugs/DB01520
    IllicitInvestigational

    It is more potent than phencyclidine and hence, this drug was classified under the schedule 1 in 1970.

  7. Drug

    CYP-001

    go.drugbank.com/drugs/DB15739
    Investigational

    These cells are then able to differentiate into bone, cartilage, and adipose tissue. The MCA-derived MSCs can be obtained from induced pluripotent stem cells (iPSCs) and then expanded in media. … These cells have advantage over other MSCs because a large amount can be obtained from a single healthy blood donor, negating the risks from donor-and expansion dependent variability.

  8. Drug

    Bafilomycin A1

    go.drugbank.com/drugs/DB06733
    Experimental

    The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. … The most commonly utilized bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

  9. Drug

    Droloxifene

    go.drugbank.com/drugs/DB15641
    Experimental

    Droloxifene has an anti-implantation effect in rats, and the effect appears to be not completely due to its anti-estrogenic activity.[L34184] … Its higher affinity to the estrogen receptor, higher anti-estrogenic to estrogenic ratio, more effective inhibition of cell growth and division in estrogen receptor-positive cell lines, and lower toxicity

  10. Drug

    Coenzyme M

    go.drugbank.com/drugs/DB09110
    ApprovedInvestigational

    Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.