DB00664ApprovedWithdrawnSmall molecule
Sulfametopyrazine is an antibiotic used in the treatment or prevention of bacterial infections and malaria. Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
- Mechanism
- Curator reviewed
Sulfametopyrazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Para-aminobenzoic acid (PABA), a substrate of the enzyme is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
- Primary indication
- For the treatment of urinary tract infection and chronic bronchitis.Curator reviewed · 2 structured indications
- Formula / weight
- C11H12N4O3S · 280.303 g/mol (avg)
- Also known as
- Sulfalene · Sulfamethopyrazine · Sulfamethoxypyrazine
- Code names
- AS-18908 · NSC-110433 · WR 4629
Resolves to
Structure
InChIKey
KXRZBTAEDBELFD-UHFFFAOYSA-NSMILESCOC1=NC=CN=C1NS(=O)(=O)C1=CC=C(N)C=C1What you can answer from here — as of September 13, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Sulfametopyrazine, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account