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Rhein
go.drugbank.com/drugs/DB13174ExperimentalRhein is an anthraquinone metabolite of rheinanthrone and senna glycoside is present in many medicinal plants including Rheum palmatum, Cassia tora, Polygonum multiflorum, and Aloe barbadensis [A19247]
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsEtravirine
go.drugbank.com/drugs/DB06414ApprovedInvestigationalEtravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). … Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseAmiodarone Action Pathway (New)
smpdb.ca/view/SMP0122646Drug actionAmiodarone may have adverse effects such as thyrotoxicosis or hypothyroidism, tremor, uncontrollable and unusual movement of the body, dizziness, headache, nausea and vomiting, constipation, blurred vision
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Dofetilide Action Pathway
smpdb.ca/view/SMP0126189Drug actionDofetilide, brand name tikosyn, is a class III antiarrhythmic agent. This drug is used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Dofetilide increases the monophasic a...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Ajmaline Action Pathway
smpdb.ca/view/SMP0126271Drug actionSome side effects of using ajmaline may include warm flushes, tingling skin, vertigo, and eye twitches. … It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Propafenone Action Pathway
smpdb.ca/view/SMP0126275Drug actionSome side effects of using propafenone may include dizziness, dry mouth, headache, and nausea.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Quinidine Action Pathway (New)
smpdb.ca/view/SMP0126282Drug actionSome side effects of using quinidine may include nausea, heartburn, fever, and dizziness. Quinidine is administered as an oral tablet.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2KB3305
go.drugbank.com/drugs/DB06349ExperimentalKB3305 is an investigational liver selective antagonist for the glucocorticoid receptor, developed by Karo Bio for the treatment of Type 2 Diabetes.
Ethyl chloride
go.drugbank.com/drugs/DB13259ApprovedWithdrawnIt was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in other commerical applications as a chemical reagent. … It is still used in the treatment of cellulose to make ethylcellulose for commercial products. Ethyl chloride is used as a diagnostic tool to detect a dead tooth with nonviable pulp.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesGTI 2040
go.drugbank.com/drugs/DB05801InvestigationalGTI-2040 is a substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antisense oligonucleotides.