This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Ethyl chloride is a local anesthetic.
- Generic Name
- Ethyl chloride
- DrugBank Accession Number
- DB13259
- Background
Ethyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in other commerical applications as a chemical reagent. It is still used in the treatment of cellulose to make ethylcellulose for commercial products. Ethyl chloride is used as a diagnostic tool to detect a dead tooth with nonviable pulp.
- Type
- Small Molecule
- Groups
- Approved, Experimental, Investigational
- Structure
Structure for Ethyl chloride (DB13259)
- Weight
- Average: 64.514
Monoisotopic: 64.007977867 - Chemical Formula
- C2H5Cl
- Synonyms
- chloroethane
- Ethyl chloride
- monochloroethane
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Therapies
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareBaclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Ethyl chloride. Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Ethyl chloride. Daridorexant The risk or severity of CNS depression can be increased when Ethyl chloride is combined with Daridorexant. Fluoxetine Ethyl chloride may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine. Haloperidol The risk or severity of CNS depression can be increased when Haloperidol is combined with Ethyl chloride. Lasmiditan The risk or severity of adverse effects can be increased when Lasmiditan is combined with Ethyl chloride. Metoclopramide The risk or severity of sedation can be increased when Metoclopramide is combined with Ethyl chloride. Oliceridine The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ethyl chloride is combined with Oliceridine. Ropeginterferon alfa-2b The risk or severity of neuropsychiatric effects can be increased when Ropeginterferon alfa-2b is combined with Ethyl chloride. Tramadol The risk or severity of CNS depression can be increased when Ethyl chloride is combined with Tramadol. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Tuffner Clear Spray Ethyl chloride (12 %) + Benzoin resin (3 %) Aerosol Topical Mueller Sports Medicine, Inc. 1970-12-31 2003-08-01 Canada 
Categories
- ATC Codes
- N01BX01 — Ethyl chloride
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as organochlorides. These are compounds containing a chemical bond between a carbon atom and a chlorine atom.
- Kingdom
- Organic compounds
- Super Class
- Organohalogen compounds
- Class
- Organochlorides
- Sub Class
- Not Available
- Direct Parent
- Organochlorides
- Alternative Parents
- Hydrocarbon derivatives / Alkyl chlorides
- Substituents
- Aliphatic acyclic compound / Alkyl chloride / Alkyl halide / Hydrocarbon derivative / Organochloride
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- chloroethanes (CHEBI:47554)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 46U771ERWK
- CAS number
- 75-00-3
- InChI Key
- HRYZWHHZPQKTII-UHFFFAOYSA-N
- InChI
- InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
- IUPAC Name
- chloroethane
- SMILES
- CCCl
References
- General References
- FDA Thailand Product Information: Ethyl chloride topical spray [Link]
- External Links
- KEGG Compound
- C18248
- PubChem Compound
- 6337
- PubChem Substance
- 347829290
- ChemSpider
- 6097
- 4141
- ChEBI
- 47554
- ChEMBL
- CHEMBL46058
- Wikipedia
- Chloroethane
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Pain 1 4 Completed Treatment Pain 1 4 Completed Treatment Pain, Acute 1 4 Completed Treatment Pain / Safety Issues / Sprays 1 4 Not Yet Recruiting Supportive Care Nail Diseases 1 4 Terminated Treatment Shoulder Pain 1 4 Unknown Status Treatment Pain on Propofol IV Injection 1 1 Withdrawn Treatment Trigger Finger 1 0 Completed Treatment Chorionic Villi Sampling 1 Not Available Completed Treatment Anesthesia therapy / Pain 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Aerosol Aerosol Topical Spray 100 ml/100ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 14.1 mg/mL ALOGPS logP 1.47 ALOGPS logP 1.19 ChemAxon logS -0.66 ALOGPS Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 16.06 m3·mol-1 ChemAxon Polarizability 6.42 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key GC-MS Spectrum - EI-B GC-MS splash10-004i-9000000000-189a942366091e0718c5 Mass Spectrum (Electron Ionization) MS splash10-004i-9000000000-11f0eb48855aebd37893 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available 1H NMR Spectrum 1D NMR Not Applicable
Drug created at June 23, 2017 20:38 / Updated at June 05, 2021 09:13