Ethyl chloride

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Ethyl chloride
Accession Number
DB13259
Description

Ethyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in other commerical applications as a chemical reagent. It is still used in the treatment of cellulose to make ethylcellulose for commercial products. Ethyl chloride is used as a diagnostic tool to detect a dead tooth with nonviable pulp.

Type
Small Molecule
Groups
Approved, Experimental, Investigational
Structure
Thumb
Weight
Average: 64.514
Monoisotopic: 64.007977867
Chemical Formula
C2H5Cl
Synonyms
  • chloroethane
  • Ethyl chloride
  • monochloroethane

Pharmacology

Pharmacology
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Indication
Not Available
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
CyclobenzaprineThe risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Ethyl chloride.
FluoxetineEthyl chloride may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
HaloperidolThe risk or severity of CNS depression can be increased when Haloperidol is combined with Ethyl chloride.
LasmiditanThe risk or severity of adverse effects can be increased when Lasmiditan is combined with Ethyl chloride.
MetoclopramideThe risk or severity of sedation can be increased when Metoclopramide is combined with Ethyl chloride.
OliceridineThe risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ethyl chloride is combined with Oliceridine.
TramadolThe risk or severity of CNS depression can be increased when Ethyl chloride is combined with Tramadol.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ethyl chloride is combined with Ziprasidone.
Interactions
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Food Interactions
Not Available

Products

Products
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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Tuffner Clear SprayEthyl chloride (12 %) + Benzoin (3 %)AerosolTopicalMueller Sports Medicine, Inc.1970-12-312003-08-01Canada flag

Categories

ATC Codes
N01BX01 — Ethyl chloride
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organochlorides. These are compounds containing a chemical bond between a carbon atom and a chlorine atom.
Kingdom
Organic compounds
Super Class
Organohalogen compounds
Class
Organochlorides
Sub Class
Not Available
Direct Parent
Organochlorides
Alternative Parents
Hydrocarbon derivatives / Alkyl chlorides
Substituents
Aliphatic acyclic compound / Alkyl chloride / Alkyl halide / Hydrocarbon derivative / Organochloride
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
chloroethanes (CHEBI:47554)

Chemical Identifiers

UNII
46U771ERWK
CAS number
75-00-3
InChI Key
HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
IUPAC Name
chloroethane
SMILES
CCCl

References

General References
  1. FDA Thailand Product Information: Ethyl chloride topical spray [Link]
KEGG Compound
C18248
PubChem Compound
6337
PubChem Substance
347829290
ChemSpider
6097
RxNav
4141
ChEBI
47554
ChEMBL
CHEMBL46058
Wikipedia
Chloroethane

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionPain1
4CompletedTreatmentPain1
4CompletedTreatmentPain, Acute1
4Not Yet RecruitingSupportive CareNail Diseases1
4RecruitingTreatmentPain / Safety Issues / Spray1
4TerminatedTreatmentShoulder Pain1
4Unknown StatusTreatmentPain on Propofol IV Injection1
2RecruitingTreatmentMechanical Neck Pain / Trigger Point Pain, Myofascial1
1WithdrawnTreatmentTrigger Finger1
0CompletedTreatmentChorionic Villi Sampling1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Aerosol
AerosolTopical
Spray
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.1 mg/mLALOGPS
logP1.47ALOGPS
logP1.19ChemAxon
logS-0.66ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity16.06 m3·mol-1ChemAxon
Polarizability6.42 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-004i-9000000000-189a942366091e0718c5
Mass Spectrum (Electron Ionization)MSsplash10-004i-9000000000-11f0eb48855aebd37893
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable

Drug created on June 23, 2017 20:38 / Updated on February 21, 2021 18:54