Ethyl chloride
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Ethyl chloride
- Accession Number
- DB13259
- Description
Ethyl chloride, or chloroethane, has a chemical formula C2H5Cl. It was commonly used in the production of tetraethyllead (TEL), which is an additive for gasoline. It was also used in other commerical applications as a chemical reagent. It is still used in the treatment of cellulose to make ethylcellulose for commercial products. Ethyl chloride is used as a diagnostic tool to detect a dead tooth with nonviable pulp.
- Type
- Small Molecule
- Groups
- Approved, Experimental, Investigational
- Structure
Structure for Ethyl chloride (DB13259)
- Weight
- Average: 64.514
Monoisotopic: 64.007977867 - Chemical Formula
- C2H5Cl
- Synonyms
- chloroethane
- Ethyl chloride
- monochloroethane
Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Indication
- Not Available
- Associated Therapies
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Reduce medical errorsand improve treatment outcomes with our comprehensive & structured data on drug adverse effects.Reduce medical errors & improve treatment outcomes with our adverse effects data- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareCyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Ethyl chloride. Fluoxetine Ethyl chloride may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine. Haloperidol The risk or severity of CNS depression can be increased when Haloperidol is combined with Ethyl chloride. Lasmiditan The risk or severity of adverse effects can be increased when Lasmiditan is combined with Ethyl chloride. Metoclopramide The risk or severity of sedation can be increased when Metoclopramide is combined with Ethyl chloride. Oliceridine The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ethyl chloride is combined with Oliceridine. Tramadol The risk or severity of CNS depression can be increased when Ethyl chloride is combined with Tramadol. Ziprasidone The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Ziprasidone. 
Improve patient outcomesBuild effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.Learn more - Food Interactions
- Not Available
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Tuffner Clear Spray Ethyl chloride (12 %) + Benzoin (3 %) Aerosol Topical Mueller Sports Medicine, Inc. 1970-12-31 2003-08-01 Canada 
Categories
- ATC Codes
- N01BX01 — Ethyl chloride
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as organochlorides. These are compounds containing a chemical bond between a carbon atom and a chlorine atom.
- Kingdom
- Organic compounds
- Super Class
- Organohalogen compounds
- Class
- Organochlorides
- Sub Class
- Not Available
- Direct Parent
- Organochlorides
- Alternative Parents
- Hydrocarbon derivatives / Alkyl chlorides
- Substituents
- Aliphatic acyclic compound / Alkyl chloride / Alkyl halide / Hydrocarbon derivative / Organochloride
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- chloroethanes (CHEBI:47554)
Chemical Identifiers
- UNII
- 46U771ERWK
- CAS number
- 75-00-3
- InChI Key
- HRYZWHHZPQKTII-UHFFFAOYSA-N
- InChI
- InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
- IUPAC Name
- chloroethane
- SMILES
- CCCl
References
- General References
- FDA Thailand Product Information: Ethyl chloride topical spray [Link]
- External Links
- KEGG Compound
- C18248
- PubChem Compound
- 6337
- PubChem Substance
- 347829290
- ChemSpider
- 6097
- 4141
- ChEBI
- 47554
- ChEMBL
- CHEMBL46058
- Wikipedia
- Chloroethane
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Pain 1 4 Completed Treatment Pain 1 4 Completed Treatment Pain, Acute 1 4 Not Yet Recruiting Supportive Care Nail Diseases 1 4 Recruiting Treatment Pain / Safety Issues / Spray 1 4 Terminated Treatment Shoulder Pain 1 4 Unknown Status Treatment Pain on Propofol IV Injection 1 2 Recruiting Treatment Mechanical Neck Pain / Trigger Point Pain, Myofascial 1 1 Withdrawn Treatment Trigger Finger 1 0 Completed Treatment Chorionic Villi Sampling 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Aerosol Aerosol Topical Spray - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 14.1 mg/mL ALOGPS logP 1.47 ALOGPS logP 1.19 ChemAxon logS -0.66 ALOGPS Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 16.06 m3·mol-1 ChemAxon Polarizability 6.42 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key GC-MS Spectrum - EI-B GC-MS splash10-004i-9000000000-189a942366091e0718c5 Mass Spectrum (Electron Ionization) MS splash10-004i-9000000000-11f0eb48855aebd37893 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available 1H NMR Spectrum 1D NMR Not Applicable
Drug created on June 23, 2017 20:38 / Updated on February 21, 2021 18:54