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Excitatory amino acid transporter 3
go.drugbank.com/bio_entities/BE0001054TargetTransporterHumansCan also transport L-cysteine (PubMed:21123949). … Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949).
Synonyms: Neuronal and epithelial glutamate transporterRibosomal protein S6 kinase alpha-4
go.drugbank.com/bio_entities/BE0004614TargetHumansPlays an essential role in the control of RELA transcriptional activity in response to TNF. … Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin.
Synonyms: Nuclear mitogen- and stress-activated protein kinase 2Zinc transporter ZIP12
go.drugbank.com/bio_entities/BE0009897TransporterHumansMay play a role in neurulation and neurite extension. … May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis
Synonyms: Zrt- and Irt-like protein 12Zinc transporter ZIP13
go.drugbank.com/bio_entities/BE0009900TransporterHumansFunctions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).
Synonyms: Zrt- and Irt-like protein 13WX-UK1
go.drugbank.com/drugs/DB05476InvestigationalIn animal models, WX-UK1 blocks tumor cell invasion, metastasis and primary tumor growth by inhibiting serine proteases and the urokinase Plasminogen Activator (uPA) system, which have been shown to play … Independent studies show that administration of Wx-UK1 resulted in a decrease of tumor cell invasion, suggesting its efficacy as a an adjuvant antimetastatic therapy of carcinomas.
Categories: Amino Acids, Peptides, and ProteinsParomomycin
go.drugbank.com/drugs/DB01421ApprovedInvestigationalAn oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Categories: Alimentary Tract and MetabolismSynonyms: Paromomycin IUdenafil
go.drugbank.com/drugs/DB06267ApprovedUdenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. … It is not yet approved for use in the U.S., E.U., or Canada.
Categories: Drugs Used in Erectile Dysfunction, Genito Urinary System and Sex HormonesProducts: ZYDENA 200MGAgkistrodon piscivorus antivenin
go.drugbank.com/drugs/DB13894ApprovedThe final purified antivenin product is obtained by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and chromatography techniques. … Approximately 99% of all venomous snake bites in the United States are caused by Crotalidae, also known as _pit vipers_.
Edotreotide gallium Ga-68
go.drugbank.com/drugs/DB15494ApprovedEdotreotide gallium Ga-68 is an 8 amino acid peptide bound to the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). … [L8597] [Dotatate gallium Ga-68] is used for a similar indication.[A185852] Dotatate gallium Ga-68 has lower tumor uptake but this data is highly variable between patients.
Tianeptine
go.drugbank.com/drugs/DB09289InvestigationalAsia (including Singapore) and Latin America as “Stablon” and “Tatinol” but it is not available in Australia, Canada, New Zealand, the U.K. or the U.S. … Currently, tianeptine is approved in France and manufactured and marketed by Laboratories Servier SA; it is also marketed in several other European countries under the trade name “Coaxil” as well as in