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Dobutamine Action Pathway (New)
smpdb.ca/view/SMP0123129Drug actionfrom both intracellular stores and through L-type calcium channels. … Dobutamine agonizes cardiac beta-1 adrenoceptors to increase intracellular via G protein-mediated cyclic AMP and protein kinase A (PKA) signaling, which increases calcium ion influx in cardiac myocytes
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GCeliprolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126652Drug actionBy blocking the beta-1 receptors the G signalling cascade is blocked, leading to decreased levels of intracellular calcium and muscle relaxation, therefore altering the heart rate.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GSotalol Action Pathway (New)
smpdb.ca/view/SMP0126230Drug actionThe L-type calcium channel is responsible for the influx of calcium from extracellular environment into the cytosol of cardiomyocytes which activates ryanodine receptors to release calcium from the sarcoplasmic … Calcium is important for the contraction of heart muscle for myosin to and actin to power-stroke so the slower influx of calcium slows down the contractions of the heart lowering the heart rate.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GAlprenolol Action Pathway
smpdb.ca/view/SMP0124510Drug actionAlprenolol is a non-selective beta blocker for the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. It can be administered intravenously or orally, where it passes through hepatic portal circulation, a...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GAtenolol Action Pathway (New)
smpdb.ca/view/SMP0126183Drug actionAtenolol is a cardioselective beta 1 blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, at...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBetaxolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126185Drug actionBetaxolol is a competitive cardioselective beta 1 blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smoo...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBisoprolol Action Pathway (New)
smpdb.ca/view/SMP0126186Drug actionBisoprolol is a cardioselective beta 1 blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, ...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GLabetalol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126203Drug actionLabetalol is a non-selective beta blocker and is a racemic mixture of 2 diastereoisomers . It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GDronedarone Multiple Ion Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126677Drug actionIt meets criteria of all four Vaughan Williams antiarrhythmic drug classes by blocking sodium, potassium, and calcium ion channels. … Cardiac action potentials are generated by ionic currents of multiple voltage-gated ion channels, including potassium, sodium, and calcium channels.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GLevobunolol Action Pathway
smpdb.ca/view/SMP0124528Drug actionLevobunolol is a ophthalmic beta-blocker, equally effective at both β(1)- and β(2)-receptor sites. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardio...
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G