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Displaying results 31 - 39 of 39 in total
  1. Pathway

    Emicizumab Action Pathway

    smpdb.ca/view/SMP0126843
    Drug action

    Emicizumab also known as Hemlibra, is a humanized recombinant monoclonal antibody that mimics coagulation factor VIII and can bind to activated coagulation factor IX and X. … It is administered subcutaneously, the antibody is metabolized through endothelial cells taking up the antibodies and degrading them into small peptides and amino acids.

    Drugs: Calcium · Emicizumab
    Enzymes: Thrombin, Fibrinogen beta chain
  2. Pathway

    Moroctocog Alfa Action Pathway

    smpdb.ca/view/SMP0126849
    Drug action

    It acts by replacing coagulation factor VIII which is deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade. … Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII similar to the endogenous coagulation factor VIII.

    Drugs: Calcium · Moroctocog alfa
    Enzymes: Thrombin, Fibrinogen beta chain
  3. Pathway

    Plasminogen

    smpdb.ca/view/SMP0130469
    Physiological

    Two major glycoforms of plasminogen are present in humans - type I plasminogen contains two glycosylation moieties (N-linked to N289 and O-linked to T346), whereas type II plasminogen contains only a single … In humans, the plasmin protein (in the zymogen form of plasminogen) is encoded by the PLG gene. Plasmin is released as a zymogen called plasminogen (PLG) from the liver into the systemic circulation.

    Drugs: Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  4. Pathway

    Protein C Action Pathway

    smpdb.ca/view/SMP0126878
    Drug action

    Protein C is also known under brand names such as Balfaxar, Beriplex, Ceprotin, Kcentra and Octaplex used to treat purpura fulminans and or coumarin-induced skin necrosis. … Due to its anticoagulant nature herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

    Drugs: Calcium · Protein C
    Enzymes: Thrombin, Fibrinogen beta chain
  5. Pathway

    Reteplase Action Pathway

    smpdb.ca/view/SMP0000285
    Drug action

    Through the two factors coagulation factor Xa and coagulation factor Va, thrombin is produced, which then uses fibrinogen alpha, beta, and gamma chains to create fibrin (loose). … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.

    Drugs: Reteplase · Phylloquinone · Calcium
    Enzymes: Thrombin, Fibrinogen gamma chain
  6. Pathway

    Alteplase Action Pathway

    smpdb.ca/view/SMP0000280
    Drug action

    Alteplase is the generic version of the drugs Activase and Actilyse. It is a thrombolytic drug prescribed to treat acute myocardial infarctions and other blood clotting conditions. … A side effect of the drug is bleeding, angioedema, allergic reactions and fever.

    Drugs: Alteplase · Phylloquinone · Calcium
    Enzymes: Thrombin, Fibrinogen gamma chain
  7. Indication

    Hemorrhage

    go.drugbank.com/conditions/DBCOND0022978
    Drugs: Aluminum sulfate · Aminocaproic acid · Antihemophilic factor (recombinant), PEGylated · Antihemophilic factor human · Antihemophilic factor, human recombinant · Beroctocog alfa +21 more
  8. Drug

    Crotalus atrox antivenin

    go.drugbank.com/drugs/DB13892
    Approved

    The final purified antivenin product is produced by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and chromatography techniques. … The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113].

  9. Target

    Prothrombin

    go.drugbank.com/bio_entities/BE0000048
    TargetEnzymeHumans

    Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. … Functions in blood homeostasis, inflammation and wound healing.