Search

Displaying results 31 - 40 of 134094 in total
  1. Pathway

    Metabolism and Physiological Effects of Hippuric Acid

    smpdb.ca/view/SMP0123209
    Metabolic

    A monocarboxylate transporter then exports hippuric acid from the liver to the blood, where it exerts toxic effects. It can reduce blood clotting and, in the kidney, inhibit organic acid secretion. … It is associated with phenylketonuria, propionic acidemia, and tyrosinemia I (genetic metabolic disorders).

    Drugs: ATP · Benzoic acid · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of Phenyl glucuronide

    smpdb.ca/view/SMP0123227
    Metabolic

    Phenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells. … When this compound returns back into systemic circulation it is shown to be a major uremic toxin through high levels of retention. Phenyl glucuronide is shown to

    Drugs: Tyrosine · Phenol · Uridine-5'-Diphosphate
  3. Pathway

    Metabolism and Physiological Effects of Indoxyl glucuronide

    smpdb.ca/view/SMP0123239
    Metabolic

    Indoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells. … After being transported into gut microbes, tryptophan undergoes a reaction with the enzyme tryptophanase to form indole.

    Drugs: Tryptophan · Indole
  4. Pathway

    Metabolism and Physiological Effects of Kynurenic Acid

    smpdb.ca/view/SMP0123300
    Metabolic

    Kynurenic acid is shown to activate aryl hydrocarbon receptors that can lead to renal impairment, and it also disrupts the electron transport chain and oxidative phosphorylation causing muscle atrophy. … After being transported into a hepatocyte from portal circulation tryptophan undergoes a reaction with the enzyme tryptophan-2,3-dioxygenase to initially form kynurenine and then with a kynurenine aminotransferase

    Drugs: Pyridoxal phosphate · Tryptophan · Kynurenine · Mesoheme
  5. Pathway

    Metabolsim and Physiological Effects of 4-Ethylphenylsulfate

    smpdb.ca/view/SMP0125541
    Metabolic

    It has also been found to be related to cardiovascular mortality and to cause cell apoptosis. … phenylalanine is consumed through foods such as milk, eggs, cheese, nuts, soybeans, chicken, beef, pork, beans and fish.

    Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 more
  6. Pathway

    Metabolism and Physiological Effects of Imidazolepropionic Acid

    smpdb.ca/view/SMP0126521
    Metabolic

    Imidazolepropionic acid, also known as deaminohistidine or 4-imidazolylpropionate (ImP), belongs to the class of organic compounds known as imidazolyl carboxylic acids and derivatives. … These are organic compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an imidazole ring.

    Drugs: Histidine
  7. Pathway

    Metabolism and Physiological Effects of N-Acetylphenylalanine

    smpdb.ca/view/SMP0126720
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free phenylalanine can also occur. … The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G).

    Drugs: Phenylalanine
  8. Pathway

    Metabolism and Physiological Effects of Phenol sulphate

    smpdb.ca/view/SMP0126844
    Metabolic

    In experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … It is a protein-bound uremic solute that induces reactive oxygen species (ROS) production and decreases glutathione levels, rendering cells vulnerable to oxidative stress.

    Drugs: Tyrosine · Phenol
  9. Pathway

    Metabolism and Physiological Effects of Androsterone sulfate

    smpdb.ca/view/SMP0127012
    Metabolic

    Androsterone has generally been considered to be an inactive metabolite of testosterone, which when conjugated by glucuronidation and sulfation allows testosterone to be removed from the body. … Approximately 50% of testosterone is metabolized via conjugation into testosterone glucuronide and to a lesser extent testosterone sulfate by glucuronosyltransferases and sulfotransferases, respectively

    Drugs: Testosterone
  10. Pathway

    2-Hydroxyglutric Aciduria (D and L Form)

    smpdb.ca/view/SMP0000136
    Disease

    A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. … A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more