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Methionine aminopeptidase 2
go.drugbank.com/bio_entities/BE0001534TargetHumansCotranslationally removes the N-terminal methionine from nascent proteins. … The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Polypeptides: Methionine aminopeptidase 2Methionine aminopeptidase 2
go.drugbank.com/bio_entities/BE0004075TargetMycobacterium tuberculosisRemoves the N-terminal methionine from nascent proteins. … Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Polypeptides: Methionine aminopeptidase 2Methionine--tRNA ligase
go.drugbank.com/bio_entities/BE0002381TargetStaphylococcus aureus (strain MRSA252)Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Polypeptides: Methionine--tRNA ligaseMethionine--tRNA ligase, cytoplasmic
go.drugbank.com/bio_entities/BE0000543EnzymeHumansCatalyzes the specific attachment of L-methionine to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the
Polypeptides: Methionine--tRNA ligase, cytoplasmicMitochondrial peptide methionine sulfoxide reductase
go.drugbank.com/bio_entities/BE0000170TargetEnzymeHumansCatalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. … Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens
Polypeptides: Mitochondrial peptide methionine sulfoxide reductaseSynonyms: Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductaseMethionine adenosyltransferase 2 subunit beta
go.drugbank.com/bio_entities/BE0002178EnzymeHumansRegulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. … Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345).
Polypeptides: Methionine adenosyltransferase 2 subunit betaSynonyms: Methionine adenosyltransferase II betaCarboxy-S-adenosyl-L-methionine synthase
go.drugbank.com/bio_entities/BE0001915TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
Polypeptides: Carboxy-S-adenosyl-L-methionine synthasePeptide methionine sulfoxide reductase MsrA
go.drugbank.com/bio_entities/BE0001618TargetShigella flexneriCatalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
Polypeptides: Peptide methionine sulfoxide reductase MsrASynonyms: Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductaseMethionine-R-sulfoxide reductase B1
go.drugbank.com/bio_entities/BE0000288EnzymeHumansMethionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. … While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue
Polypeptides: Methionine-R-sulfoxide reductase B1Free methionine-R-sulfoxide reductase
go.drugbank.com/bio_entities/BE0003187TargetEscherichia coli (strain K12)Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
Polypeptides: Free methionine-R-sulfoxide reductaseFunction: L-methionine-(R)-S-oxide reductase activity