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Ondansetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126768Drug actionOndansetron acts both centrally and peripherally to prevent and treat nausea and vomiting. Central effects are mediated by the antagonism of 5HT-3 serotonin receptors in the area postrema. The area postrema, located on the fourth ventric...
Dolasetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126782Drug actionDolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The a...
Vortioxetine Serotonin Action Action Pathway
smpdb.ca/view/SMP0126788Drug actionVortioxetine is classified as a serotonin modulator and simulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhi...
Pipotiazine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126800Drug actionPipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic...
Olanzapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126804Drug actionOlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potent...
Mirtazapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126817Drug actionThe mechanism of action of mirtazapine, atypical antidepressant is not fully understood, but may be explained by its effects on central adrenergic and serotonergic activity. This drug exhibits a fast onset of action, a high level of resp...
Minaprine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126818Drug actionMinaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree...
Cyproheptadine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126842Drug actionCyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors. Antagonism of serotonin on the appetite center of the hypothalamus may ...
Isoniazid Action Pathway
smpdb.ca/view/SMP0718080Drug actionIsoniazid is an antibiotic used to treat the mycobacterial infection tuberculosis. After oral ingestion it begins its mechanism of action as a prodrug. It needs to be activated by the bacterial catalase KatG. Once it is activated it init...
Streptomycin Tuberculosis Action Pathway
smpdb.ca/view/SMP0718084Drug actionThis pathway illustrates the multifaceted interactions between streptomycin—an aminoglycoside antibiotic—and Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), highlighting its antibacterial mechanism, molecular targets, and downstr...