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Displaying results 31 - 40 of 296 in total
  1. Target

    Sodium/Potassium Transporting ATPase

    go.drugbank.com/bio_entities/BE0010055
    TargetTransporterHumans

    Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity … May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase

    Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-2Synonyms: Sodium pump subunit alpha-1, Sodium pump subunit alpha-2
  2. Target

    Epithelial sodium channel subunit beta

    go.drugbank.com/bio_entities/BE0000024
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247).

    Polypeptides: Epithelial sodium channel subunit betaSynonyms: Amiloride-sensitive sodium channel subunit beta, Nonvoltage-gated sodium channel 1 subunit beta
  3. Target

    Hepatic sodium/bile acid cotransporter

    go.drugbank.com/bio_entities/BE0003644
    TransporterTargetHumans

    It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). … fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774).

    Polypeptides: Hepatic sodium/bile acid cotransporterSynonyms: Sodium/taurocholate cotransporting polypeptide
  4. Target

    Sodium-driven chloride bicarbonate exchanger

    go.drugbank.com/bio_entities/BE0004683
    TransporterHumans

    Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). … Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity).

    Polypeptides: Sodium-driven chloride bicarbonate exchangerFunction: sodium,bicarbonate
  5. Target

    Sodium-coupled monocarboxylate transporter 1

    go.drugbank.com/bio_entities/BE0004708
    TransporterHumans

    Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate … Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324). Part of D-serine transport systems.

    Polypeptides: Sodium-coupled monocarboxylate transporter 1Synonyms: Sodium iodide-related cotransporter, Electrogenic sodium monocarboxylate cotransporter
  6. Target

    Epithelial sodium channel subunit delta

    go.drugbank.com/bio_entities/BE0000495
    TargetHumans

    sodium balance and fluid homeostasis (PubMed:16423824, PubMed:19520916, PubMed:7499195). … This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels (PubMed:7499195)

    Polypeptides: Epithelial sodium channel subunit deltaSynonyms: Amiloride-sensitive sodium channel subunit delta, Nonvoltage-gated sodium channel 1 subunit delta
  7. Target

    Sodium-dependent organic anion transporter

    go.drugbank.com/bio_entities/BE0004710
    TransporterHumans

    Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:17491011, PubMed:23667501, PubMed:24717977, PubMed … Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (PubMed:17491011)

    Polypeptides: Sodium-dependent organic anion transporter
  8. Target

    Sodium-dependent phosphate transporter 1

    go.drugbank.com/bio_entities/BE0005055
    TransporterHumans

    May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). … Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632,

    Polypeptides: Sodium-dependent phosphate transporter 1
  9. Target

    Sodium-dependent phosphate transporter 2

    go.drugbank.com/bio_entities/BE0008680
    TransporterHumans

    Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, … Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity).

    Polypeptides: Sodium-dependent phosphate transporter 2
  10. Target

    P-type sodium-transporting ATPase4

    go.drugbank.com/bio_entities/BE0009185
    TargetPlasmodium falciparum (isolate 3D7)

    Sodium-exporting ATPase (PubMed:23414762, PubMed:29986883, PubMed:31311978, PubMed:36180431).

    Polypeptides: P-type sodium-transporting ATPase4Function: ABC-type sodium transporter activity