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Displaying results 4021 - 4030 of 10000 in total
  1. Drug

    Tebentafusp

    go.drugbank.com/drugs/DB15283
    ApprovedInvestigational

    This approval marks the first bispecific T cell engager to be approved by the FDA to treat a solid tumour and being the first and only therapy for the treatment of unresectable or metastatic uveal melanoma … [L39995] It is a bispecific, fusion protein and first-in-class drug of immune-mobilizing monoclonal T cell receptors against cancer (ImmTACs), a recently developed cancer immunotherapy with a novel mechanism

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents
  2. Drug

    Periciazine

    go.drugbank.com/drugs/DB01608
    Approved

    It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. … It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system.

  3. Indication

    Diffuse Large B-Cell Lymphoma (DLBCL)

    go.drugbank.com/conditions/DBCOND0028221
    Drugs: Glofitamab · Hyaluronidase (ovine) · Rituximab
    Synonyms: Malignant lymphoma, large cell, cleaved and noncleaved, Malignant lymphoma - large cell cleaved and non-cleaved
  4. Drug

    Streptococcus pneumoniae type 19a capsular polysaccharide antigen

    go.drugbank.com/drugs/DB10337
    ApprovedInvestigational

    It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia. … Streptococcus pneumoniae type 19a capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 19a of *Streptococcus pneumoniae

    Mixtures: PNEUMOVAX 23 Injektionslösung in einer Fertigspritze, PNEUMOVAX 23 Injektionslösung in einer Durchstechflasche
  5. Target

    Amino acid transporter heavy chain SLC3A1

    go.drugbank.com/bio_entities/BE0001130
    TransporterHumans

    SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (PubMed:10588648, PubMed:11318953, PubMed:16609684 … SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity

    Synonyms: Neutral and basic amino acid transport protein
  6. Target

    Serine/threonine-protein kinase 26

    go.drugbank.com/bio_entities/BE0004109
    TargetHumans

    STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. … Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)

    Synonyms: MST3 and SOK1-related kinase
  7. Target

    Cytohesin-3

    go.drugbank.com/bio_entities/BE0004433
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3
  8. Target

    Anoctamin-1

    go.drugbank.com/bio_entities/BE0004746
    TargetHumans

    Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). … Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity

    Synonyms: Tumor-amplified and overexpressed sequence 2
  9. Drug

    Iomeprol

    go.drugbank.com/drugs/DB11705
    ApprovedInvestigational

    [A265090,A265095] Iomeprol first appeared in the market in 1994 [A265095] and is currently used in various diagnostic processes involving x-ray imaging and computed tomography (CT) scans.[L52260] … [L52260] Iomeprol demonstrates low chemotoxicity, osmolality and viscosity and high water solubility.

    Categories: Compounds used in a research, industrial, or household settingSynonyms: N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-5-(N-METHYLGLYCOLAMIDO)ISOPHTHALAMIDE, 1,3-BENZENEDICARBOXAMIDE, N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-((HYDROXYACETYL)METHYLAMINO)-2,4,6-TRIIODO-
  10. Drug

    Inbakicept

    go.drugbank.com/drugs/DB16479
    Investigational

    [A263617, A263622] Inbakicept, in combination with nogapendekin alfa, mimics the actions of IL-15, stimulating the activation and proliferation of natural killer cells and CD8+ memory T cells, which also … [L50592] This combination product was approved by the FDA on April 22, 2024, for the treatment of BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without

    Synonyms: N-803 COMPONENT IL-15R.ALPHA.SU/FC FUSION PROTEIN, ALT-803 COMPONENT IL-15R.ALPHA.SU/FC FUSION PROTEINCategories: Amino Acids, Peptides, and Proteins