Search

Displaying results 4081 - 4090 of 10000 in total
  1. Drug

    Tigecycline

    go.drugbank.com/drugs/DB00560
    ApprovedInvestigational

    Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.

    Synonyms: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamideProducts: TIGEVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE, TIGECICLINA 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE
  2. Drug

    Ezeprogind

    go.drugbank.com/drugs/DB16954
    Investigational

    Synonyms: N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo(d)imidazol-2-amine, 1,4-piperazinedipropanamine, n'-1h-benzimidazol-2-yl-n,n-bis(2-methylpropyl)-
  3. Target

    Biliverdin reductase A

    go.drugbank.com/bio_entities/BE0000741
    TargetEnzymeHumans

    Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666,

    Polypeptides: Biliverdin reductase ASynonyms: BVR A
  4. Target

    Apolipoprotein A-II

    go.drugbank.com/bio_entities/BE0000922
    TargetHumans

    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism

    Polypeptides: Apolipoprotein A-II
  5. Target

    Thromboxane-A synthase

    go.drugbank.com/bio_entities/BE0001893
    TargetHumans

    Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:11097184, PubMed:11297515, PubMed:22735388, … Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same

    Polypeptides: Thromboxane-A synthase
  6. Target

    Alpha-galactosidase A

    go.drugbank.com/bio_entities/BE0002422
    TargetEnzymeHumans

    Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome

    Polypeptides: Alpha-galactosidase ASynonyms: Alpha-D-galactosidase A
  7. Target

    Surface protein A

    go.drugbank.com/bio_entities/BE0002809
    TargetNeisseria meningitidis

    Polypeptides: Surface protein A
  8. Target

    Apolipoprotein A-I

    go.drugbank.com/bio_entities/BE0003449
    CarrierTargetEnzymeHumans

    Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase

    Polypeptides: Apolipoprotein A-I
  9. Target

    Prelamin-A/C

    go.drugbank.com/bio_entities/BE0010877
    TargetHumans

    Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner … Lamin A and C also regulate matrix stiffness by conferring nuclear mechanical properties (PubMed:23990565, PubMed:25127216).

    Polypeptides: Prelamin-A/C
  10. Drug

    Pegvorhyaluronidase alfa

    go.drugbank.com/drugs/DB14912
    Investigational

    Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection

    Synonyms: ALFA, SUBSTITUTED ON N6 OF AN AVERAGE OF 4 TO, HUMAN HYALURONIDASE PH-20 (HYALURONOGLUCOSAMINIDASE PH-20, SPERM ADHESION MOLECULE 1, EC 3.2.1.35) PRECURSOR-(36-482)-PEPTIDE (MATURE (1-447)-PEPTIDE), PRODUCED IN CHINESE HAMSTER OVARY (CHO) CELLS, GLYCOFORM