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Displaying results 4131 - 4140 of 10000 in total
  1. Drug

    Pregabalin

    go.drugbank.com/drugs/DB00230
    ApprovedInvestigational

    Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. … [A187190] Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent

    Mixtures: PREPLUS B12 75 MG/1 MG EFERVESAN TABLET, 14 ADET, PAGAMAX PLUS 150 MG/1 MG KAPSÜL ,60 KAPSÜLSynonyms: (S)-3-Isobutyl GABA, 3-Isobutyl GABA
  2. Target

    Hexokinase-4

    go.drugbank.com/bio_entities/BE0001056
    TargetEnzymeHumans

    Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). … Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:11916951, PubMed:15277402, PubMed:18322640, PubMed:25015100,

    Polypeptides: Hexokinase-4
  3. Target

    Stathmin-4

    go.drugbank.com/bio_entities/BE0004003
    TargetHumans

    Exhibits microtubule-destabilizing activity

    Polypeptides: Stathmin-4
  4. Target

    Reticulon-4

    go.drugbank.com/bio_entities/BE0010844
    TargetHumans

    Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262...

    Polypeptides: Reticulon-4
  5. Target

    Mucin-4

    go.drugbank.com/bio_entities/BE0018599
    TargetHumans

    The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. … Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978).

    Polypeptides: Mucin-4Synonyms: MUC-4
  6. Indication

    Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug

    go.drugbank.com/conditions/DBCOND0154352
    Drugs: Pretomanid
    Synonyms: Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug
  7. Drug

    Xylometazoline

    go.drugbank.com/drugs/DB06694
    Approved

    Xylometazoline works by binding to alpha (α)-adrenergic receptors to cause vasoconstriction of nasal blood vessels. … Xylometazoline is an imidazoline derivative [A228523] with sympathomimetic and nasal decongestant activity.

    Mixtures: Ophtrivin A Ophthalmic Dps, NASOWELL 1 MG/ML+ 50 MG/ML BURUN SPREYİ, ÇÖZELTİ, 1 ADETCategories: Adrenergic alpha-1 Receptor Agonists, Heterocyclic Compounds, 1-Ring
  8. Drug

    Tinidazole

    go.drugbank.com/drugs/DB00911
    ApprovedInvestigational

    A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections.

    Mixtures: TRİVAG 300 MG / 200 MG/ 100 MG OVÜL, 3 ADET, GYNOMAX 100 MG/150 MG VAJINAL OVUL, 7 ADETCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  9. Target

    Ribonuclease 4

    go.drugbank.com/bio_entities/BE0001924
    TargetHumans

    Cleaves preferentially after uridine bases (PubMed:3467790). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:33818125). Probably contributes to urinary tract sterility (PubMed:33818125)

    Polypeptides: Ribonuclease 4Synonyms: RNase 4
  10. Target

    Interleukin-4

    go.drugbank.com/bio_entities/BE0003520
    TargetHumans

    In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). … Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell

    Polypeptides: Interleukin-4Synonyms: IL-4