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Displaying results 4151 - 4160 of 10000 in total
  1. Target

    Nectin-4

    go.drugbank.com/bio_entities/BE0009798
    TargetHumans

    Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells

    Polypeptides: Nectin-4Synonyms: Nectin cell adhesion molecule 4, Poliovirus receptor-related protein 4
  2. Target

    Phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0011004
    TargetHumans

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes … Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes

  3. Drug

    Aluminum oxide

    go.drugbank.com/drugs/DB11342
    ApprovedWithdrawn

    Aluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. … It is considered an indirect additive used in food contact substances by the FDA.

    Mixtures: POLGENTEC 2-120 GBQ GENERADOR DE RADIONUCLEIDOSProducts: ALUTACID ANTACID MIXTURE 4% w/w, ALUMINIUM HYDROXIDE MIXTURE BP 4% w/w
  4. Drug

    Pralidoxime

    go.drugbank.com/drugs/DB00733
    ApprovedInvestigationalVet approved

    Pralidoxime is an antidote to organophosphate pesticides and chemicals. … If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase

    Categories: Compounds used in a research, industrial, or household settingSynonyms: 2-PAM
  5. Drug

    Olopatadine

    go.drugbank.com/drugs/DB00768
    Approved

    It is a structural analog of [doxepin], which has a minimal anti-allergic activity. … [A1172] In comparison to other anti-allergenic ophthalmic medications, olopatadine displays a good comfort and tolerability profile since it does not cause perturbation of cell membranes.

    Mixtures: OFNOL FRESH % 0.1 + %0.15 STERİL OFTALMİK ÇÖZELTİ, 1 ADETCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  6. Target

    Hexokinase-4

    go.drugbank.com/bio_entities/BE0001056
    TargetEnzymeHumans

    Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). … Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues (PubMed:11916951, PubMed:15277402, PubMed:18322640, PubMed:25015100,

    Polypeptides: Hexokinase-4
  7. Target

    Stathmin-4

    go.drugbank.com/bio_entities/BE0004003
    TargetHumans

    Exhibits microtubule-destabilizing activity

    Polypeptides: Stathmin-4
  8. Target

    Reticulon-4

    go.drugbank.com/bio_entities/BE0010844
    TargetHumans

    Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262...

    Polypeptides: Reticulon-4
  9. Target

    Mucin-4

    go.drugbank.com/bio_entities/BE0018599
    TargetHumans

    The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. … Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978).

    Polypeptides: Mucin-4Synonyms: MUC-4
  10. Indication

    Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug

    go.drugbank.com/conditions/DBCOND0154352
    Drugs: Pretomanid
    Synonyms: Pulmonary Tuberculosis resistant to isoniazid, rifamycins, a fluoroquinolone and a second line injectable antibacterial drug